Fig. 3
Comparison of antibody breadth and potency against a panel of 21 HIV-1 pseudoviruses. A IC50 heat map of the parental monoclonal antibodies alone, iMab and N6; antibody combination iMab + N6; and the bibNAb iMab-N6. The numbers in brackets next to iMab + N6 represent the fold difference in potency (red = enhancement, black = reduction) of iMab-N6 over iMab + N6. The numbers in brackets next to iMab-N6 represent the fold difference in potency (green = no enhancement) of iMab-N6 over parental N6 and iMab antibodies, respectively. Individual cells are colour-coded according to IC50 potency (number), with lower numbers and darker red representing greater potency. ND not done. B Scatter plot depicting IC50 values of dual sensitive HIV-1 pseudoviruses for each antibody with the median and IQR shown. Comparisons were done using non-parametric t-test (Wilcoxon matched-pairs signed rank test) with *p < 0.0167 and ***p < 0.001