Table 1 Baseline characteristics and outcomes
Overall (n = 241) | Covid-19 (n = 146) | Influenza (n = 95) | p value | |
|---|---|---|---|---|
Age—years | 62 [53–70] | 65 [55–72] | 59 [51–65] | < 0.001 |
Male | 158 (65.5) | 99 (67.8) | 59 (62.1) | 0.44 |
Medical history | ||||
Hypertension | 95 (39.4) | 71 (48.6) | 24 (25.2) | < 0.001 |
Diabetes mellitus | 48 (19.9) | 36 (24.7) | 12 (12.6) | 0.03 |
Obesity | 128 (53.1) | 106 (72.6) | 22 (23.2) | < 0.01 |
Neurological medical history | 35 (14.5) | 18 (12.3) | 17 (17.9) | 0.31 |
BMI—kg/m2 | 28.2 [24.6–32.0] | 28.7 [25.9–32.9] | 27.0 [23.8–31.2] | 0.05 |
GCS at admission | 15 [15–15] | 15 [15–15] | 15 [14, 15] | 0.001 |
Severity during the first 24 h | ||||
SAPS II | 37 [28–49] | 33 [24–42] | 46 [35–60] | < 0.001 |
SOFA | 6 [4–8] | 4 [3–7] | 9 [7–11] | < 0.001 |
Worst PaO2/FiO2—mmHg | 97.5 [74.0–131.8] | 105.5 [83.0–142.3] | 84.0 [63.3–114.8] | < 0.001 |
Agitation | 111 (46.2) | 80 (54.8) | 31 (33.0) | < 0.001 |
Administration of anti-agitative drug | 100 (42.6) | 76 (53.9) | 24 (25.5) | < 0.001 |
Sedation | ||||
Length of sedation—days | 10 [6–17] | 11 [6–17] | 10 [5–15] | 0.12 |
Cumulative doses of morphine—mg | 987 [521–2345] | 975 [530–2187] | 1200 [434–2868] | 0.81 |
Cumulative doses of midazolam—mg | 980 [503–2326] | 966 [503–2164] | 1162 [514–2753] | 0.70 |
Cumulative doses of propofol—mg | 13,135 [1426–13607] | 6938 [1694–16375] | 3400 [1050–7550] | 0.01 |
Length of MV—days | 13 [8–23] | 13 [8–21] | 14 [9–24] | 0.24 |
Length of stay in ICU—days | 15 [10–28] | 15 [10–26] | 17 [9–28] | 0.94 |
Length of ileus—days | 6 [4–9] | 7 [5–10] | 6 [4–9] | 0.07 |
Self-extubation | 21 (8.8) | 13 (9.0) | 8 (8.4) | 1.00 |
28-days survival | 210 (87.1) | 133 (91.1) | 77 (81.1) | 0.04 |