Fig. 5

Identification of the novel W box at the C terminus of HDV-III HDAg-L. A The CHC interaction motifs of HDV-I, HDV-II, and HDV-III HDAg-L. The clathrin box (green rectangles) in HDV-I and -II HDAg-L, and the novel W box (red rectangle) in HDV-III HDAg-L are indicated. B Phylogenetic tree of HDAg-L. Unique C-terminal sequences of HDAg-L were analyzed using the neighbor joining method. The conventional HDV-I, -II, -III HDAg-L sequences (red dots) was clustered with other unique HDAg-L sequences (black dots) in clade 1 (shaded in orange), clade 2 (shaded in green), and in clade 3 (shaded in blue) as indicated. C Sequence logos of HDAg-L. The clathrin box (green rectangles) in clade 1 and 2 and the novel W box box (red rectangle) in clade 3 are indicated, respectively