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Fig. 1 | Virology Journal

Fig. 1

From: The envelope protein of Zika virus interacts with apolipoprotein E early in the infectious cycle and this interaction is conserved on the secreted viral particles

Fig. 1

Kinetics of ApoE and Zika E protein colocalization and evidence of their interaction in infected Huh7.5 cells. a Kinetics of the colocalization of the ApoE and Zika E proteins, from 6 to 48 h post-infection at an MOI of 1. Scale bars = 8 µm. b Pearson coefficients for the colocalization of ApoE and Zika E protein within the ROI in Huh7.5 cells were performed on 30 z-stacks per condition. ****: p value < 0.0001 in ANOVA tests. c Co-immunoprecipitation of ApoE and Zika E protein. NI: naive cells; Inf: infected cells; IP: immunoprecipitation; anti-ApoE: goat anti-ApoE Abs; anti-gp120: anti-HIV-1 gp120 Abs used as an isotype control for the immunoprecipitation assay

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