Fig. 4
From: A chimeric MERS-CoV virus-like particle vaccine protects mice against MERS-CoV challenge
Chimeric MERS-CoV VLP immunization reduced histopathological changes and virus titers in the lung. A Representative images of H&E-stained lung sections from chimeric MERS-CoV VLP-immunized, PBS-immunized, or mock-infected hDPP4 KI mice at 3 days after MA MERS-CoV challenge. B Summary scores for disease in the lung sections. n = 3 mice/group. C At 3 days after virus challenge, virus lung titers were quantified using a plaque assay. The results are expressed as the mean (n = 3) ± SD. LOD, limit of detection. Statistical significance was assessed using Student’s t test. *, P < 0.05