Fig. 2
From: A chimeric MERS-CoV virus-like particle vaccine protects mice against MERS-CoV challenge
Chimeric MERS-CoV VLP immunization induced the production of S-specific IgG and neutralizing antibodies. A Schematic diagram of the immunization protocol. C57BL/6 mice were intramuscularly immunized with chimeric MERS-CoV VLPs or PBS. At 28 days post-immunization, serum samples were collected. B Endpoint titers of MERS S-specific IgG were measured by ELISA. C Detection of neutralizing antibody titers in the serum of the immunized mice using a pseudovirus neutralization test. The results are expressed as the mean (n = 4) NT50 ± SD. D Endpoint titers of MERS S-specific IgG1 and IgG2a were measured by ELISA. Statistical significance was assessed using Student’s t test. *, P < 0.05, **, P < 0.01; ***, P < 0.001; ns, not significant