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Fig. 9 | Virology Journal

Fig. 9

From: Enhanced synergistic antitumor effect of a DNA vaccine with anticancer cytokine, MDA-7/IL-24, and immune checkpoint blockade

Fig. 9

The impact of IL-10 blockade on anti-tumoral responses. A IFN-γ level in DNA E7&IL-24 (P < 0.001) and IL-24 (P < 0.05) groups highly increased when coupled with IL-10 blockade. B IL-10 level in DNA E7&IL-24 (P < 0.05) groups significantly decreased when coupled with IL-10 blockade. C The concentration of caspase-9 increased in DNA E7&IL-24 (P < 0.001) and IL-24 (P < 0.05) groups when treated with anti-IL-10 in comparison with isotype control. Also, D tumor volume regressed in DNA E7&IL-24 (P < 0.001), DNA E7 (P < 0.01) and IL-24 (P < 0.05) groups when treated with anti-IL-10 in comparison with isotype groups. These data are representative means ± SD of three independent experiments *P < 0.05; **P < 0.01; ***P < 0.001

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