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Fig. 3 | Virology Journal

Fig. 3

From: Enhanced synergistic antitumor effect of a DNA vaccine with anticancer cytokine, MDA-7/IL-24, and immune checkpoint blockade

Fig. 3

CTL activities of spleen lymphocytes from the tumor-bearing mice were determined by LDH release assay. Splenocytes from immunized mice were isolated one week after last treatment and incubated with EL4 cells; then, pulsed with synthetic E7 specific epitope (H-2Db CTL epitope) at 50:1 effector-(splenocytes)-to-target (EL4) cell (E/T) ratios. Splenocytes derived from immunized mice with DNA E7 plus IL-24 showed higher cytotoxicity against E7 specific epitope re-stimulation than those from the other groups. ***Statistically significant differences between the E7 DNA plus IL-24 compared with other groups (DNA E7, IL-24, pcDNA, PBS) as determined by one-way ANOVA (P < 0.001)

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Virology Journal

ISSN: 1743-422X