Skip to main content

Table 1 Diagnostic and clinical characteristics of the three episodes and follow-up appointments

From: Recurrent parvovirus B19 viremia resulting in two episodes of hemophagocytic lymphohistiocytosis

Parameter

Unit

reference values

1st episode

follow-up

2nd episode

follow-up

3rd episode

   

(t0)

2 months

12 months

15 months

21 months

CRP

mg/dl

 < 0.5

12.2

 < 0.1

1.3

 < 0.1

1.5

PCT

ng/ml

 < 0.05

10.38

..

0.18

..

..

LDH

U/l

 < 247

2844

215

653

..

337

GOT (AST)

U/l

 < 31

2635

17

105

15

31

Ferritin

µg/l

13,0–150,0

24,068#

179.4

9864#

65.2

1323#

sCD25 (sIL-2R)

kU/l

158–623

3822#

..

1136

..

490

White blood count

nl−1

4–11

0.6

4.4

2.6

10.7

5.8

Neutrophiles

nl−1

2.0–8.3

0.3#

..

1.2

..

4.22

Platelets

nl−1

150–400

48#

212

66#

247

179

Hemoglobine

g/dl

11.9–14.6

6.3#

13.4

11.0

14.4

10.5

Fibrinogen

mg/dl

210–400

236

..

254

..

401

Triglycerides

mg/dl

 < 150

229

54

140

..

..

NK cell activity

 

..

..

..

..

..

Normal

Parvovirus B19-DNA

IU/ml

Negative

1761

Negative

275

..

2

Temperature

°C

 

40.4#

 

39.0#

 

36.6

Spleen length

mm

 < 110

161#

112

124#

 

109

Liver size (cc and dv in MCL)

mm

 

( +) 110/167

112/144

122/128

 

131/140

Hemophagocytosis

Yes/no

No

(−)*

 

..

 

..

HLH2004

n

 < 5

5

 

3

 

1

Hscore

n

 

264

 

193

 

19

Corresp. likelihood

%

 

 > 99

 

80–88

 

 < 1

  1. CRP: c reactive protein; PCT: procalcitonin; LDH: lactate dehydrogenase; sCD25 (sIL-2R): soluble CD25 (soluble interleukin-2 receptor); WBC: white blood count; cc: cranio-caudal; dv: dorso-ventral; MCL: mid-clavicular line; ..: no data/not conducted. *: aspirate of low quality and therefore not diagnostically conclusive. Values in bold: pathologic findings (values beyond laboratory reference ranges). #: meeting corresponding HLH-2004 criteria