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Table 2 Ivermectin compared to control for COVID-19 patients

From: Ivermectin under scrutiny: a systematic review and meta-analysis of efficacy and possible sources of controversies in COVID-19 patients

Patient or population: COVID-19
Intervention: Ivermectin
Comparison: Standard of care or Placebo
Outcomes No of participants
(studies)
Follow up
Certainty of the evidence
(GRADE)
Ref
Mortality 3472
(10 RCTs)

Very lowa,b
[19, 24, 34, 36,37,38,39, 41, 43, 47]
Progression to severe or critical state 3594
(9 RCTs)

Lowa,b
[19, 24, 34, 36,37,38, 41, 44, 47]
Negative RT-PCR 2679
(9 RCTs)

Very lowa,b,c
[24, 33, 38, 41,42,43,44, 46]
Recovery 1125
(4 RCTs)

Lowa,b
[19, 37, 38, 42]
Duration of hospitalization 908
(5 RCTs)

Very lowa,b,d
[19, 34, 36, 45, 47]
Time to negative RT-PCR 138
(3 RCTs)

Lowa,e
[33, 40, 45]
Viral load 200
(2 RCTs)

Lowb,e
[20, 42]
  1. Explanations
  2. GRADE Working Group grades of evidence
  3. High certainty We are very confident that the true effect lies close to that of the estimate of the effect
  4. Moderate certainty We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different
  5. Low certainty Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect
  6. Very low certainty We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect
  7. aThe proportion of information from studies at high risk of bias is sufficient to affect the interpretation of results. Crucial limitation for one criterion, or some limitations for multiple criteria, sufficient to lower confidence in the estimate of effect. Downgraded one or two levels based on the number of high-risk of bias studies
  8. bWide confidence interval (uncertainty about magnitude of effect). Downgraded one level
  9. cModerate heterogeneity. Downgraded one level
  10. dHigh heterogeneity. Downgraded two level
  11. eSmall sample size. Downgraded one level