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Table 5 Association of neurological symptoms with herpesvirus reactivation

From: Herpesvirus and neurological manifestations in patients with severe coronavirus disease

Virus Central nervous system p Peripheral nervous system p Total
Yes
N (%)
No
N (%)
Yes
N (%)
No
N (%)
HSV-1
Yes 3 (33.3) 6 (66.8) 0.684a 2 (22.2) 7 (77.8) 0.129a 9 (100)
No 11 (25) 33 (75)   2 (4.5) 42 (95.5)   44 (100)
HSV-2
Yes 1 (100) 0 (0) 0.264a 0 (0) 1 (100) 0.999a 1 (100)
No 13 (25) 39 (75)   4 (7.7) 48 (92.3)   52 (100)
EBV
Yes 5 (33.3) 10 (66.7) 0.504a 0 (0) 15 (100) 0.568a 15 (100)
No 9 (23.7) 29 (76.3)   4 (10.5) 34 (89.5)   38 (100)
CMV
Yes 9 (39.1) 14 (60.9) 0.066b 0 (0) 23 (100) 0.124a 23 (100)
No 5 (16.7) 25 (83.3)   4 (13.3) 26 (86.7)   30 (100)
VZV
Yes 2 (50) 2 (50) 0.282a 0 (0) 4 (100) 0.999a 4 (100)
No 12 (24.5) 37 (75.5)   4 (8.2) 45 (91.8)   49 (100)
HHV-6
Yes 10 (40) 15 (60) 0.034b* 0 (0) 25 (100) 0.113 a 25 (100)
No 4 (14.3) 24 (85.7)   4 (14.3) 24 (85.7)   28 (100)
HHV-7
Yes 8 (38.1) 13 (61.9) 0.118b 1 (4.8) 20 (95.2) 0.999a 21 (100)
No 6 (18.8) 26 (81.2)   3 (9.4) 29 (90.6)   32 (100)
HHV-8
Yes 3 (33.3) 6 (66.7) 0.684b 0 (0) 9 (100) 0.999a 9 (100)
No 11 (25.0) 33 (75.0)   4 (9.1) 40 (90.9)   44 (100)
  1. SARS-CoV-2 severe acute respiratory syndrome coronavirus 2, HSV herpes simplex virus, VZV varicella zoster virus, EBV Epstein–Barr virus, CMV cytomegalovirus, HHV human herpesvirus
  2. *Statistical significance
  3. aFisher's exact test; bPearson's Chi-square test