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Table 5 Association of neurological symptoms with herpesvirus reactivation

From: Herpesvirus and neurological manifestations in patients with severe coronavirus disease

Virus

Central nervous system

p

Peripheral nervous system

p

Total

Yes

N (%)

No

N (%)

Yes

N (%)

No

N (%)

HSV-1

Yes

3 (33.3)

6 (66.8)

0.684a

2 (22.2)

7 (77.8)

0.129a

9 (100)

No

11 (25)

33 (75)

 

2 (4.5)

42 (95.5)

 

44 (100)

HSV-2

Yes

1 (100)

0 (0)

0.264a

0 (0)

1 (100)

0.999a

1 (100)

No

13 (25)

39 (75)

 

4 (7.7)

48 (92.3)

 

52 (100)

EBV

Yes

5 (33.3)

10 (66.7)

0.504a

0 (0)

15 (100)

0.568a

15 (100)

No

9 (23.7)

29 (76.3)

 

4 (10.5)

34 (89.5)

 

38 (100)

CMV

Yes

9 (39.1)

14 (60.9)

0.066b

0 (0)

23 (100)

0.124a

23 (100)

No

5 (16.7)

25 (83.3)

 

4 (13.3)

26 (86.7)

 

30 (100)

VZV

Yes

2 (50)

2 (50)

0.282a

0 (0)

4 (100)

0.999a

4 (100)

No

12 (24.5)

37 (75.5)

 

4 (8.2)

45 (91.8)

 

49 (100)

HHV-6

Yes

10 (40)

15 (60)

0.034b*

0 (0)

25 (100)

0.113 a

25 (100)

No

4 (14.3)

24 (85.7)

 

4 (14.3)

24 (85.7)

 

28 (100)

HHV-7

Yes

8 (38.1)

13 (61.9)

0.118b

1 (4.8)

20 (95.2)

0.999a

21 (100)

No

6 (18.8)

26 (81.2)

 

3 (9.4)

29 (90.6)

 

32 (100)

HHV-8

Yes

3 (33.3)

6 (66.7)

0.684b

0 (0)

9 (100)

0.999a

9 (100)

No

11 (25.0)

33 (75.0)

 

4 (9.1)

40 (90.9)

 

44 (100)

  1. SARS-CoV-2 severe acute respiratory syndrome coronavirus 2, HSV herpes simplex virus, VZV varicella zoster virus, EBV Epstein–Barr virus, CMV cytomegalovirus, HHV human herpesvirus
  2. *Statistical significance
  3. aFisher's exact test; bPearson's Chi-square test