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Table 3 Association of corticosteroid use and lymphocytopenia with herpesvirus reactivation

From: Herpesvirus and neurological manifestations in patients with severe coronavirus disease

Viral type Corticosteroid use p Lymphocytopenia   p Total
Yes
N (%)
No
N (%)
Yes
N (%)
No
N (%)
HSV-1
Yes 8 (88.9) 1 (11.1) 0.129a 6 (66.7) 3 (33.3) 0.474a 9 (100)
No 25 (56.8) 19 (43.2)   22 (50) 22 (50)   44 (100)
HSV-2
Yes 1 (100) 0 (0) 1.000a 1 (100) 0 (0) 1.000a 1 (100)
No 32 (61.5) 20 (38.5)   27 (51.9) 25 (48.1)   52 (100)
EBV
Yes 11 (73.3) 4 (26.7) 0.296b 10 (66.7) 5 (33.3) 0.205b 15 (100)
No 22 (57.9) 16 (42.1)   18 (47.4) 20 (52.6)   38 (100)
CMV
Yes 12 (52.2) 11 (47.8) 0.185b 11 (47.8) 12 (52.2) 0.523b 23 (100)
No 21 (70) 9 (30)   17 (56.7) 13 (43.3)   30 (100)
VZV
Yes 2 (50) 2 (50) 0.627a 3 (75) 1 (25) 0.613a 4 (100)
No 31 (63.3) 18 (36.7)   25 (51) 24 (49)   49 (100)
HHV-6
Yes 14 (56) 11 (44) 0.374b 12 (48) 13 (52) 0.506b 25 (100)
No 19 (67.9) 9 (32.1)   16 (57.1) 12 (42.9)   28 (100)
HHV-7
Yes 14 (66.7) 7 (33.3) 0.592b 8 (381) 13 (61.9) 0.082b 21 (100)
No 19 (59.4) 13 (40.6)   20 (62.5) 12 (37.5)   32 (100)
HHV-8
Yes 5 (55.6) 4 (44.4) 0.715b 2 (22.2) 7 (77.8) 0.087b 9 (100)
No 28 (63.6) 16 (36.4)   26 (59.1) 18 (40.9)   44 (100)
  1. HSV herpes simplex virus, VZV varicella zoster virus, EBV Epstein–Barr virus, CMV cytomegalovirus, HHV human herpesvirus
  2. aFisher's exact test; bPearson's Chi-square test