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Fig. 1 | Virology Journal

Fig. 1

From: Identification and application of a pair of noncompeting monoclonal antibodies broadly binding to the nucleocapsid proteins of SARS-CoV-2 variants including Omicron

Fig. 1

A pair of noncompeting mAbs binding to the SARS-CoV-2 and SARS-CoV NPs. a Binding affinities of P301-F7 and P301-H5 to NPs of SARS-CoV-2 (upper) and SARS-CoV (lower) by SPR. The data are means of three independent experiments. b Gene family analysis of P301-F7 and P301-H5. c P301-F7 and P301-H5 bound to two distinct epitopes on the SARS-CoV-2 NP (upper) and SARS-CoV NP (lower) by competition SPR. The experiment was performed twice and one representative result was shown. d Predicted model of the SARS-CoV-2 NP recognized by P301-F7 (brown) and P301-H5 (purple). The model was predicted using Alphafold 2.0 based on the N-terminal and C-terminal molecular structures (PDB codes: 7CDZ and 7CE0)

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Virology Journal

ISSN: 1743-422X