Fig. 6
From: All-trans retinoic acid increases the pathogenicity of the H9N2 influenza virus in mice
Effects of therapeutic dose of ATRA on lung histopathology of mice infected with H9N2 virus. a–h are histopathology images of the lungs of mice at 5 days after inoculation. a. Blank group, mice receiving sterile PBS inoculation and cottonseed oil injection at 0–9 days after inoculation; b–d ATRA1-ATRA3 group, mice receiving sterile PBS inoculation and ATRA injection (1, 5, and 10 mg/kg, respectively) at 0–9 days after inoculation; e H9N2 group, mice receiving H9N2 virus (105.5 TCID50) inoculation and cottonseed oil injection at 0–9 days after inoculation; f–h ATRA1 + H9N2-ATRA3 + H9N2 group, mice receiving H9N2 virus (105.5 TCID50) inoculation and ATRA injection (1, 5, and 10 mg/kg, respectively) at 0–9 days after inoculation. H&E stain. Original magnification × 200. n = 5. ATRA, all-trans retinoic acid; TCID50, median tissue culture infective dose