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Fig. 6 | Virology Journal

Fig. 6

From: All-trans retinoic acid increases the pathogenicity of the H9N2 influenza virus in mice

Fig. 6

Effects of therapeutic dose of ATRA on lung histopathology of mice infected with H9N2 virus. ah are histopathology images of the lungs of mice at 5 days after inoculation. a. Blank group, mice receiving sterile PBS inoculation and cottonseed oil injection at 0–9 days after inoculation; bd ATRA1-ATRA3 group, mice receiving sterile PBS inoculation and ATRA injection (1, 5, and 10 mg/kg, respectively) at 0–9 days after inoculation; e H9N2 group, mice receiving H9N2 virus (105.5 TCID50) inoculation and cottonseed oil injection at 0–9 days after inoculation; fh ATRA1 + H9N2-ATRA3 + H9N2 group, mice receiving H9N2 virus (105.5 TCID50) inoculation and ATRA injection (1, 5, and 10 mg/kg, respectively) at 0–9 days after inoculation. H&E stain. Original magnification × 200. n = 5. ATRA, all-trans retinoic acid; TCID50, median tissue culture infective dose

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