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Fig. 5 | Virology Journal

Fig. 5

From: A novel cocktail therapy based on quintuplet combination of oncolytic herpes simplex virus-2 vectors armed with interleukin-12, interleukin-15, GM-CSF, PD1v, and IL-7 × CCL19 results in enhanced antitumor efficacy

Fig. 5

Therapeutic effects of cocktail therapy in the 4T1 model. Balb/c mice were subcutaneously implanted by 4T1 tumor cells and intratumorally injected with OVs on days 1, 2, 3, 8, 10, 15, 17, 19 (n = 4–5 per group). A Schematic depiction of the experiment. B Tumor volume growth curves of the OVs and mock-treated groups, data are shown as mean + SD. ***P < 0.001 (vs 5voHSV2 group) by repeated-measures 2-way ANOVA with Bonferroni’s correction. C The mice tumor volumes on day 37 from the control and OVs treated groups in (B). ***P < 0.001 by unpaired t-test. D Survival is shown by Kaplan–Meier analysis. *P < 0.05 (vs. 5voHSV2 group) by log-rank test

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Virology Journal

ISSN: 1743-422X