Table 9 Comparison of lymphocyte subsets and cytokines of late-ICU group from hospital admission to ICU admission (n = 14)
From: Characteristics of lymphocyte subsets and cytokine profiles of patients with COVID-19
Characteristic | Hospital admission | ICU admission | Z value | P value |
|---|---|---|---|---|
Lymphocyte classification | Â | Â | Â | Â |
Lymphocyte, median (IQR), × 106/L | 561.00 (477.00–767.00) | 498.50 (301.00–712.50) |  − 1.682 | 0.093 |
CD3+, median (IQR), × 106/L | 347.00 (254.25–520.50) | 267.00 (117.50–499.25) |  − 1.784 | 0.074 |
CD4+, median (IQR), × 106/L | 236.00 (152.25–369.25) | 174.00 (56.25–273.50) |  − 1.784 | 0.074 |
CD8+, median (IQR), × 106/L | 125.00 (86.75–185.00) | 101.00 (51.25–190.75) |  − 1.580 | 0.114 |
CD19+, median (IQR), × 106/L | 108.50 (85.75–136.00) | 98.50 (58.50–122.50) |  − 1.887 | 0.059 |
NK, median (IQR), × 106/L | 99.50 (77.25–124.25) | 97.00 (57.75–125.25) |  − 0.866 | 0.386 |
CD3+, median (IQR),% | 67.31 (54.31–69.75) | 54.72 (40.50–70.09) |  − 2.191 | 0.028 |
CD4+, median (IQR),% | 40.69 (26.76–49.50) | 33.60 (22.43–39.50) |  − 2.293 | 0.022 |
CD8+, median (IQR),% | 21.88 (17.25–26.61) | 19.91 (14.78–26.61) |  − 1.479 | 0.139 |
CD19+, median (IQR),% | 16.82 (12.84–23.31) | 19.32 (11.66–26.93) |  − 1.478 | 0.139 |
NK, median (IQR),% | 16.25 (8.95–24.06) | 19.40 (10.79–29.06) | 2.293 | 0.022 |
CD4+/CD8+, median (IQR) | 1.90 (1.14–2.67) | 1.74 (1.09–1.92) |  − 2.191 | 0.028 |
Cytokine profiles | Â | Â | Â | Â |
IL-4, median (IQR), pg/mL | 1.42 (1.23–2.21) | 1.81 (1.34–2.43) | 1.992 | 0.046 |
IL-6, median (IQR), pg/mL | 19.01 (13.26–57.87) | 16.87 (4.13–69.75) |  − 0.314 | 0.753 |
IL-10, median (IQR), pg/mL | 3.69 (3.12–4.81) | 3.63 (2.75–6.00) |  − 0.734 | 0.463 |
IL-17, median (IQR), pg/mL | 1.17 (0.95–1.39) | 1.24 (1.03–1.53) | 1.572 | 0.116 |
TNF-α, median (IQR), pg/mL | 2.89 (1.22–5.93) | 3.75 (2.66–5.66) | 0.943 | 0.345 |
IFN-γ, median (IQR), pg/mL | 3.37 (2.08–11.80) | 4.12 (2.08–10.70) | 0.943 | 0.345 |