Table 8 Comparison of lymphocyte subsets and cytokines between direct-ICU and late-ICU groups on hospital admission
From: Characteristics of lymphocyte subsets and cytokine profiles of patients with COVID-19
Characteristic | Direct-ICU group (n = 33) | Late-ICU group (n = 20) | Z value | P value |
|---|---|---|---|---|
Lymphocyte classification | Â | Â | Â | Â |
Lymphocyte, median (IQR), × 106/L | 681.00 (480.50–965.50) | 578.50 (489.50–820.25) | − 0.706 | 0.480 |
CD3+, median (IQR), × 106/L | 430.00 (220.50–571.50) | 357.00 (264.00–573.50) | − 0.505 | 0.614 |
CD4+, median (IQR), × 106/L | 282.00 (145.00–350.50) | 236.00 (154.50–367.75) | − 0.422 | 0.673 |
CD8+, median (IQR), × 106/L | 145.00 (95.00–225.50) | 135.00 (90.75–185.00) | − 0.340 | 0.734 |
CD19+, median (IQR), × 106/L | 119.00 (77.50–156.50) | 102.00 (72.25–130.75) | − 1.000 | 0.317 |
NK, median (IQR), × 106/L | 86.00 (60.00–175.00) | 103.00 (82.25–124.75) | 0.284 | 0.776 |
CD3+, median (IQR),% | 61.22 (53.58–67.36) | 66.93 (55.12–69.16) | 1.229 | 0.219 |
CD4+, median (IQR),% | 37.78 (29.39–42.93) | 38.36 (27.61–46.54) | 0.440 | 0.660 |
CD8+, median (IQR),% | 20.60 (17.11–28.12) | 23.09 (17.65–29.87) | 0.706 | 0.480 |
CD19+, median (IQR),% | 17.98 (15.78–22.67) | 15.35 (11.19–20.80) | − 1.596 | 0.110 |
NK, median (IQR),% | 16.68 (9.62–26.46) | 18.95 (12.06–22.85) | 0.037 | 0.971 |
CD4+/CD8+, median (IQR) | 1.53 (1.15–2.43) | 1.55 (1.10–2.51) | − 0.303 | 0.762 |
Cytokine profiles | Â | Â | Â | Â |
IL-4, median (IQR), pg/mL | 1.68 (1.31–2.47) | 1.64 (1.20–2.36) | − 0.725 | 0.468 |
IL-6, median (IQR), pg/mL | 10.12 (2.52–43.99) | 20.48 (14.27–51.22) | 1.517 | 0.129 |
IL-10, median (IQR), pg/mL | 3.76 (2.79–5.17) | 3.85 (3.09–4.90) | 0.339 | 0.734 |
IL-17, median (IQR), pg/mL | 1.15 (1.04–1.36) | 1.21 (0.96–1.43) | 0.073 | 0.941 |
TNF-α, median (IQR), pg/mL | 3.12 (1.88–5.04) | 2.97 (1.30–5.84) | − 0.028 | 0.978 |
IFN-γ, median (IQR), pg/mL | 5.18 (1.77–8.72) | 3.73 (2.61–8.73) | 0.009 | 0.993 |