Table 2 Comparison of laboratory findings between non-ICU and ICU groups on hospital admission
From: Characteristics of lymphocyte subsets and cytokine profiles of patients with COVID-19
Characteristic | Normal range | Total (n = 214) | Non-ICU group (n = 161) | ICU group (n = 53) | P value |
|---|---|---|---|---|---|
Blood routine | Â | Â | Â | Â | Â |
White blood cell, median (IQR), × 109/L | 3.50–9.50 | 5.20 (4.10–6.70) | 5.10 (4.10–6.60) | 5.40 (4.35–6.95) | 0.490 |
Neutrophil, median (IQR), × 109/L | 1.80–6.30 | 3.56 (2.58–4.88) | 3.46 (2.51–4.40) | 4.21 (2.97–5.66) | 0.006 |
Lymphocyte, median (IQR), × 109/L | 1.10–3.20 | 1.08 (0.80–1.53) | 1.20 (0.90–1.60) | 0.75 (0.55–1.04) |  < 0.001 |
Monocyte, median (IQR), × 109/L | 3.00–10.00 | 0.37 (0.29–0.48) | 0.39 (0.31–0.48) | 0.33 (0.19–0.48) | 0.016 |
Platelet, median (IQR), × 109/L | 125.00–350.00 | 176.50 (138.00–236.25) | 186.00 (146.50–238.00) | 150.00 (118.00–229.50) | 0.045 |
Neutrophil, median (IQR), % | 40.00–75.00 | 69.15 (60.68–78.75) | 65.80 (58.70–73.45)) | 79.90 (70.05–84.90) |  < 0.001 |
Lymphocyte, median (IQR), % | 20.00–50.00 | 22.65 (14.30–29.20) | 24.80 (17.95–30.65) | 13.50 (10.05–21.50) |  < 0.001 |
Monocyte, median (IQR),% | 3.00–10.00 | 7.10 (5.50–9.20) | 7.30 (6.00–9.25) | 5.70 (3.90–8.45) | 0.001 |
NLR, median (IQR), % | NA | 3.05 (2.07–5.34) | 2.55 (1.85–4.09) | 5.94 (3.26–8.50) |  < 0.001 |
Lymphocytopenia, n (%) | NA | 187 (87.4) | 136 (84.5) | 51 (96.2) | 0.025 |
Thrombopenia, n (%) | NA | 36 (16.8) | 21 (13.0) | 15 (28.3) | 0.011 |
Blood biochemistry | Â | Â | Â | Â | Â |
Urea nitrogen, median (IQR), mmol/L | 3.10–8.00 | 4.00 (3.20–5.20) | 3.90 (3.20–4.95) | 4.50 (3.05–5.90) | 0.160 |
Creatinine, median (IQR), mmol/L | 57.00–97.00 | 66.00 (55.00–75.25) | 66.00 (56.00–76.50) | 65.00 (50.00–75.00) | 0.435 |
TBil, median (IQR), umol/L | 0.00–26.00 | 9.60 (6.38–15.93) | 9.60 (5.95–16.05) | 10.00 (6.80–15.20) | 0.768 |
DBil, median (IQR), umol/L | 0.00–8.00 | 4.70 (3.28–6.40) | 4.50 (3.10–6.20) | 5.10 (3.65–8.15) | 0.033 |
ALT, median (IQR), U/L | 9.00–50.00 | 21.20 (14.68–35.13) | 19.70 (14.65–33.35) | 26.00 (13.55–39.30) | 0.218 |
AST, median (IQR), U/L | 15.00–40.00 | 23.50 (17.18–34.18) | 20.80 (16.50–28.70) | 34.00 (25.60–44.50) |  < 0.001 |
CK, median (IQR), U/L | 50.00–310.00 | 62.00 (42.00–90.00) | 60.00 (42.00–84.05) | 77.00 (40.50–159.50) | 0.067 |
CKMB, median (IQR), U/L | 0.00–25.00 | 12.00 (10.00–16.00) | 12.00 (10.00–16.00) | 14.00 (9.90–17.00) | 0.530 |
HbA1c, median (IQR),% |  | 5.60 (5.30–5.90) | 5.50 (5.30–5.80) | 5.90 (5.60–7.15) |  < 0.001 |
Infection related parameters | Â | Â | Â | Â | Â |
CRP, median (IQR), mg/L | 0.00–8.00 | 11.63 (2.12–50.89) | 5.99 (1.72–20.43) | 81.05 (46.12–131.49) |  < 0.001 |
PCT, median (IQR), ng/mL |  < 0.046 | 0.04 (0.03–0.07) | 0.04 (0.03–0.06) | 0.09 (0.06–0.14) |  < 0.001 |
Coagulation function | Â | Â | Â | Â | Â |
PT, median (IQR), s | 8.00–14.00 | 11.10 (10.60–11.43) | 11.00 (10.55–11.35) | 11.30 (10.65–11.80) | 0.019 |
APTT, median (IQR), s | 20.00–40.00 | 26.50 (24.50–29.30) | 26.10 (23.90–28.40) | 29.00 (26.30–33.50) |  < 0.001 |
D-dimer, median (IQR), mg/L | 0.00–0.55 | 0.37 (0.20–0.60) | 0.28 (0.19–0.47) | 0.62 (0.44–1.30) |  < 0.001 |