Fig. 3
From: Clinical and molecular aspects of human pegiviruses in the interaction host and infectious agent
The life cycle of the Flaviviridae. a Virus binding and endocytosis mediated by receptor. b Acid-catalyzed fusion and disassembly in the endosome. c Release of RNA genome into the cytoplasm. d Viral RNA translation and polyprotein processing. e RNA genome replication on intracellular membranes. f Progeny virus assembly and budding into endoplasmic reticulum(ER). g Virus transport and maturation through the cell secretory pathway. h Virus release at the cell surface