Table 4 Sensitivity, specificity, positive predicted value, and negative predicted value
From: Comparison of six antibody assays and two combination assays for COVID-19
Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | |
|---|---|---|---|---|
Total | ||||
Elecsys | 91.3% (88.1–94.0%) | 100% (96.4–100%) | 100% (98.9–100%) | 75.2% (67.0–82.3%) |
SuperFlex_Ab | 94.8% (92.0–96.8%) | 100% (96.4–100%) | 100% (99.0–100%) | 83.3% (75.4–89.5%) |
SuperFlex_IgM | 36.5% (31.6–41.5%) | 99.0% (94.6–100%) | 99.3% (96.1–100%) | 29.0% (24.3–34.2%) |
SuperFlex_IgG | 90.8% (87.5–93.5%) | 100% (96.4–100%) | 100% (98.9–100%) | 74.1% (65.8–81.2%) |
SuperFlex_any* | 95.3% (92.6–97.2%) | 99.0% (94.6–100%) | 99.7% (98.5–100%) | 84.6% (76.8–90.6%) |
iFlash_IgM | 40.7% (35.7–45.8%) | 100% (96.4–100%) | 100% (97.6–100%) | 30.7% (25.7–36.0%) |
iFlash_IgG | 94.5% (91.7–96.6%) | 100% (96.4–100%) | 100% (99.0–100%) | 82.6% (74.7–88.9%) |
iFlash_any# | 94.5% (91.7–96.6%) | 100% (96.4–100%) | 100% (99.0–100%) | 82.6% (74.7–88.9%) |
Day 1–14 | ||||
Elecsys | 77.4% (68.2–84.9%) | 100% (96.4–100%) | 100% (95.6–100%) | 80.6% (72.6–87.2%) |
SuperFlex_Ab | 82.1% (73.4–88.8%) | 100% (96.4–100%) | 100% (95.8–100%) | 84.0% (76.2–90.1%) |
SuperFlex_IgM | 19.8% (12.7–28.7%) | 99.0% (94.6–100%) | 95.5% (77.2–99.9%) | 53.8% (46.3–61.2%) |
SuperFlex_IgG | 67.9% (58.2–76.7%) | 100% (96.4–100%) | 100% (95.0–100%) | 74.6% (66.4–81.7%) |
SuperFlex_any* | 84.0% (75.6–90.4%) | 99.0% (94.6–100%) | 98.9% (94.0–100%) | 85.3% (77.6–91.2%) |
iFlash_IgM | 39.6% (30.3–49.6%) | 100% (96.4–100%) | 100% (91.6–100%) | 61.0% (53.1–68.5%) |
iFlash_IgG | 84.9% (76.6–91.1%) | 100% (96.4–100%) | 100% (96.0–100%) | 86.2% (78.6–91.9%) |
iFlash_any# | 84.9% (76.6–91.1%) | 100% (96.4–100%) | 100% (96.0–100%) | 86.2% (78.6–91.9%) |
Day 15–182 | ||||
Elecsys | 96.7% (93.9–98.5%) | 100% (96.4–100%) | 100% (98.6–100%) | 91.7% (84.9–96.2%) |
SuperFlex_Ab | 99.6% (98.0–100%) | 100% (96.4–100%) | 100% (98.7–100%) | 99.0% (94.6–100%) |
SuperFlex_IgM | 42.9% (37.0–49.0%) | 99.0% (94.6–100%) | 99.2% (95.4–100%) | 38.7% (32.7–44.9%) |
SuperFlex_IgG | 99.6% (98.0–100%) | 100% (96.4–100%) | 100% (98.7–100%) | 99.0% (94.6–100%) |
SuperFlex_any* | 99.6% (98.0–100%) | 99.0% (94.6–100%) | 99.6% (98.0–100%) | 99.0% (94.6–100%) |
iFlash_IgM | 41.1% (35.2–47.2%) | 100% (96.4–100%) | 100% (96.8–100%) | 38.2% (32.3–44.3%) |
iFlash_IgG | 98.2% (95.8–99.4%) | 100% (96.4–100%) | 100% (98.6–100%) | 95.2% (89.2–98.4%) |
iFlash_any# | 98.2% (95.8–99.4%) | 100% (96.4–100%) | 100% (98.6–100%) | 95.2% (89.2–98.4%) |