Table 3 Antiviral activities of compounds against DENV-2 and ZIKV
From: Searching for plant-derived antivirals against dengue virus and Zika virus
Compounds | DENV-2 | ZIKV | CC50 (µM) | |||||
|---|---|---|---|---|---|---|---|---|
EC50 (µM) | Virucidal activity | SI | EC50 (µM) | Virucidal activity | SI | BHK-21 | Vero | |
Lycorine | 0.5 | No | 8.6 | 0.9 | No | 3.8 | 4.3 | 3.4 |
Rutine | Inactive | No | – | Inactive | NT | – | > 300 | > 300 |
Pretazettine | 0.8 | No | 6.8 | 1.9 | No | 3.8 | 5.4 | 7.2 |
Narciclasine | 0.02 | No | 4.5 | 0.02 | No | 6.0 | 0.09 | 0.12 |
Narciclasine-4-O-β-D-xylopyranoside | 7.9 | No | 4.9 | 7.9 | No | 6.5 | 39.3 | 51.8 |
1-acetyl-lycorine* | Inactive | No | – | 19.3 | No | 1.0 | 7.8 | 19.8 |
1,2-diacetyl-lycorine* | Inactive | No | – | Inactive | No | – | > 100 | > 100 |