Table 2 Clinical presentation and complications of immunosuppressed patients with influenza infections
All types (n = 111) | Malignancies (n = 71) | HSCT (n = 26) | Autoimmune disorders (n = 10) | |
|---|---|---|---|---|
Fever (%) | 103/111 (92.8) | 69/71 (97.2) | 22/26 (84.6) | 8/10 (80.0) |
Sore throat (%) | 16/72 (22.2) | 11/50 (22.0) | 2/14 (14.3) | 2/7 (28.6) |
Rhinorrhoea (%) | 20/73 (27.4) | 8/49 (16.3) | 6/16 (37.5) | 4/7 (57.1) |
Cough (%) | 44/87 (50.6) | 22/54 (40.7) | 16/22 (72.7) | 5/9 (55.6) |
Headache (%) | 16/71 (22.5) | 8/48 (16.7) | 2/13 (15.4) | 5/9 (55.6) |
Muscle soreness (%) | 22/68 (32.4) | 14/49 (28.6) | 3/13 (23.1) | 3/5 (60.0) |
Dyspnoea (%) | 13/76 (17.1) | 4/51 (7.8) | 8/19 (42.1) | 0/5 (0.0) |
Gastrointestinal symptoms (%) | 12/78 (15.4) | 6/52 (11.5) | 6/19 (31.6) | 0/5 (0.0) |
Altered mental status (%) | 6/95 (6.3) | 2/58 (3.4) | 3/24 (12.5) | 0/10 (0.0) |
Symptom onset, hours (range) | 24.0 (2.0–456.0) | 24.0 (6.0–312.0) | 60.0 (24.0–456.0) | 24.0 (2.0–96.0) |
Coinfection with other pathogens (%) | 21/111 (18.9) | 10/71 (14.1) | 11/26 (42.3) | 0/10 (0.0) |
Complications (%) | 45/111 (40.5) | 22/71 (31.0) | 17/26 (65.4) | 4/10 (40.0) |
Pneumonia on chest radiograph or CT scan (%) | 42/98 (42.9) | 21/61 (34.4) | 16/24 (66.7) | 4/9 (44.4) |
Acute respiratory distress syndrome (%) | 10/111 (9.0) | 3/71 (4.2) | 7/26 (26.9) | 0/10 (0.0) |
Shock (%) | 7/111 (6.3) | 2/71 (2.8) | 3/26 (11.5) | 0/10 (0.0) |
Acute kidney injury (%) | 4/111 (3.6) | 0/71 (0.0) | 2/26 (7.7) | 1/10 (10.0) |
Viral encephalitis (%) | 1/111 (0.9) | 0/71 (0.0) | 1/26 (3.8) | 0/10 (0.0) |
Admission to the ICU (%) | 16/111 (14.4) | 8/71 (11.3) | 7/26 (26.9) | 0/10 (0.0) |
Mechanical ventilation (%) | 9/111 (8.1) | 2/71 (2.8) | 7/26 (26.9) | 0/10 (0.0) |
Virus detection turning negative, days (range)* | 3.0 (1.0–11.0) | 3.0 (1.0–11.0) | 3.0 (1.0–9.0) | 7.0 (2.0–9.0) |
Number of hospitalization days (range) | 15.0 (1.0–130.0) | 12.0 (1.0–65.0) | 44.0 (1.0–130.0) | 10.5 (4.0–56.0) |
Death (%) | 11/111 (9.9) | 4/71 (5.6) | 7/26 (26.9) | 0/10 (0.0) |