Table 9 Effect of Amino-acid substution on T-cell epitopes of HPV-33 E6
From: The polymorphism analysis and epitope predicted of Alphapapillomavirus 9 E6 in Sichuan, China
Substution | HPV-33 E6 | ||
|---|---|---|---|
Epitopes | Alles | Effection | |
K35N | 35-43KPLQRSEVY | HLA-C*03:02 | Disappear |
35-49NPLQRSEVYDFAFAD | HLA-DQA1*01:01/DQB1*02:01 | Affinity decreased | |
S74T | 68-76RFLSKITEY | HLA-B*46:01 | Better affinity |
69-76FLSKITEY | HLA-B*46:01 | ||
69-77FLSKITEYR | HLA-A*33:03 | ||
68-77RFLSKITEYR | HLA-A*33:03 | ||
68-76RFLSKITEY | HLA-B*15:02 | ||
68-76RFLSKITEY | HLA-A*24:02 | ||
68-76RFLSKITEY | HLA-C*03:02 | ||
69-76FLSKITEY | HLA-C*03:02 | ||
62-76ICKLCLRFLSKISEY | HLA-DRB1*14:01 | Disappear | |
69-79FLSKISEYRHY | HLA-B*15:02 | ||
74-83SEYRHYNYSV | HLA-B*40:01 | ||
73-81ITEYRHYNY | HLA-C*03:02 | Affinity decreased | |
63-77CKLCLRFLSKITEYR | HLA-DRB1*12:02 | ||
64-78KLCLRFLSKITEYRH | HLA-DRB1*12:02 | ||
62-76ICKLCLRFLSKITEY | HLA-DRB1*12:02 | ||
61-75GICKLCLRFLSKITE | HLA-DRB1*12:02 | ||
65-79LCLRFLSKITEYRHY | HLA-DRB1*12:02 | ||
60-74FGICKLCLRFLSKIT | HLA-DRB1*12:02 | ||
66-80CLRFLSKITEYRHYN | HLA-DRB1*12:02 | ||
64-78KLCLRFLSKITEYRH | HLA-DRB1*14:01 | ||
63-77CKLCLRFLSKITEYR | HLA-DRB1*14:01 | ||
65-79LCLRFLSKITEYRHY | HLA-DRB1*14:01 | ||
N86H | 81-88YSVYGHTL | HLA-C*03:02 | Better affinity |
81-88YSVYGHTL | HLA-C*01:02 | ||
81-88YSVYGHTL | HLA-C*03:04 | ||
81-88YSVYGHTL | HLA-C*08:01 | ||
80-88NYSVYGHTL | HLA-A*24:02 | ||
78-88HYNYSVYGHTL | HLA-A*24:02 | ||
79-88YNYSVYGHTL | HLA-A*24:02 | ||
N86H | 82-92SVYGHTLEQTV | HLA-A*02:01 | Better affinity |
83-92VYGHTLEQTV | HLA-A*24:02 | Affinity decreased | |
84-92YGHTLEQTV | HLA-C*08:01 | ||
77-88RHYNYSVYGHTL | HLA-A*24:02 | New epitopes | |
82-90SVYGHTLEQ | HLA-A*11:01 | ||
81-88YSVYGHTL | HLA-B*46:01 | ||
80-88NYSVYGHTL | HLA-C*01:02 | ||
N86H/K93N | 86-94HTLEQTVNK | HLA-A*11:01 | Better affinity |
85-94GHTLEQTVNK | HLA-A*11:01 | ||
86-94HTLEQTVNK | HLA-A*33:03 | ||
83-94VYGHTLEQTVNK | HLA-A*11:01 | Affinity decreased | |
86-96HTLEQTVNKPL | HLA-B*40:01 | New epitopes | |
82-93SVYGNTLEQTVK | HLA-A*11:01 | Disappear | |
K93N | 88-96LEQTVNKPL | HLA-B*40:01 | Better affinity |
85-94GNTLEQTVNK | HLA-A*11:01 | ||
86-94NTLEQTVNK | HLA-A*11:01 | ||
86-94NTLEQTVNK | HLA-A*33:03 | Affinity decreased | |
91-102TVNKPLNEILIR | HLA-A*33:03 | ||
83-94VYGNTLEQTVNK | HLA-A*11:01 | ||
82-94SVYGNTLEQTVNK | HLA-A*11:01 | ||
91-99TVNKPLNEI | HLA-C*08:01 | New epitopes | |
91-99TVNKPLNEI | HLA-B*13:01 | ||
91-99TVNKPLNEI | HLA-C*03:04 | ||
91-99TVNKPLNEI | HLA-C*01:02 | ||
87-96TLEQTVNKPL | HLA-B*40:01 | ||
82-93SVYGNTLEQTVK | HLA-A*11:01 | Disappear | |
Q113R | 113-121REKKRHVDL | HLA-B*40:01 | Better affinity |
R145I | 141-149RSRRIETAL | HLA-C*03:04 | Better affinity |
141-149RSRRRETAL | HLA-C*01:02 | Disappear | |