Table 11 Effect of Amino-acid substution on T-cell epitopes of HPV-58 E6
From: The polymorphism analysis and epitope predicted of Alphapapillomavirus 9 E6 in Sichuan, China
Substution | HPV-58 E6 | ||
|---|---|---|---|
Epitopes | Alles | Effection | |
D86E | 81-88YSLYGETL | HLA-C*03:04 | better affinity |
84-92YGETLEQTL | HLA-C*08:01 | ||
81-88YSLYGETL | HLA-C*08:01 | ||
80-88NYSLYGETL | HLA-A*24:02 | ||
79-88YNYSLYGETL | HLA-A*24:02 | ||
78-88HYNYSLYGETL | HLA-A*24:02 | ||
83-92LYGETLEQTL | HLA-A*24:02 | Affinity decreased | |
82-91SLYGETLEQT | HLA-A*02:01 | ||
84-92YGETLEQTL | HLA-C*03:04 | ||
81-88YSLYGETL | HLA-C*01:02 | ||
82-92SLYGETLEQTL | HLA-B*13:01 | ||
85-92GETLEQTL | HLA-B*40:01 | New epitopes | |
81-88YSLYGETL | HLA-C*03:02 | ||
84-92YGETLEQTL | HLA-C*01:02 | ||
84-92YGDTLEQTL | HLA-C*03:02 | Disappear | |
D86E/K93N | 85-94GETLEQTLNK | HLA-A*11:01 | Better affinity |
86-94ETLEQTLNK | HLA-A*11:01 | ||
82-94SLYGETLEQTLNK | HLA-A*11:01 | Affinity decreased | |
84-94YGETLEQTLNK | HLA-A*11:01 | ||
85-96GETLEQTLNKCL | HLA-B*40:01 | New epitopes | |
86-94ETLEQTLNK | HLA-A*33:03 | ||
82-93SLYGDTLEQTLK | HLA-A*11:01 | Disappear | |
K93N | 88-96LEQTLNKCL | HLA-B*40:01 | Better affinity |
85-94GDTLEQTLNK | HLA-A*11:01 | ||
84-94YGDTLEQTLNK | HLA-A*11:01 | Affinity decreased | |
82-94SLYGDTLEQTLNK | HLA-A*11:01 | ||
91-99TLNKCLNEI | HLA-A*02:01 | New epitopes | |
82-93SLYGDTLEQTLK | HLA-A*11:01 | Disappear | |
R145K | 137-145AVCWRPRRK | HLA-A*11:01 | New epitopes |
137-145AVCWRPRRR | HLA-A*33:03 | Disappear | |