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Table 1 Nucleotide mutation and amino acid substitution in HPV-16 E6

From: The polymorphism analysis and epitope predicted of Alphapapillomavirus 9 E6 in Sichuan, China

 

HPV-16 E6

No

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

17

18

19

20

21

Location

2

12

30

49

94

96

96

96

101

103

103

111

185

192

194

196

253

268

313

360

452

Mutation

T–A

G–A

G–A

A–G

G–A

T–A

T–G

T–C

T–G

T–G

T–C

T–C

G–T

G–T

A–G

C–G

C–T

T–G

G–C

A–C

G–C

Frequency (%)

0.80

3.20

0.80

0.80

0.80

0.80

49.6

0.80

0.80

0.80

0.80

1.60

0.80

0.80

1.60

0.80

0.80

5.60

0.80

5.60

0.80

Substitution

M1K

–

–

R17G

D32N

D32E

D32E

D32E

I34R

L35V

L35V

–

R62I

–

N65S

P66A

H85Y

L90V

D105H

E120D

R151T

  1. Compared with the HPV-16 E6 reference sequence (NC001526), the mutations are marked with the corresponding bases and amino acid, and those without changes are replaced with a dash (–). No. means the number of nucleotide mutations, Location means the sites of nucleotide mutations, Mutation means the style of nucleotide mutations, Frequency (%) means the percentage of nucleotide mutations, Substitution means the amino acid substitution that occurred by nucleotide mutations