Fig. 1
From: 3C protease of enterovirus 71 cleaves promyelocytic leukemia protein and impairs PML-NBs production
EV71 3C protease cleaves PML. A Structure of the PML isoforms. The diagram presents the exon composition of different mRNA variants coding seven PML isoforms (PMLI–VIIb) and the protein length. Light color is used to highlight the difference of their 3′-terminus. The domains, the motifs, and amino acid (aa) positions relative to the PMLI are shown, including RBCC motif, NLS, NES, SIM, two breakpoints in APL, and three major (K65, K160, and K490) SUMOylation sites. B Co-transfection analysis of six nuclear isoforms of PML and 3C or 3C (E71A) mutant. Cell lysates of HEK293T were tested by Western blotting after 36 h of transfection