Table 2 Detailed nucleotide site with mutation rate changed significantly during MTCT
Case | Mutants | MR (mother) | MR (7-month-old infants) | MR change | P | Amino acid substitution |
|---|---|---|---|---|---|---|
Pair 1 | G375T | 0.06 | 0.38 | 0.32 | 0.028 | sW74L |
C2102T | 0.12 | 0.46 | 0.34 | 0.039 | non | |
Pair 2 | C339A | 0.00 | 0.58 | 0.58 | < 0.001 | sP62L |
T2555C | 0.00 | 0.42 | 0.42 | 0.001 | non | |
A2590T | 0.00 | 0.42 | 0.42 | 0.001 | pY95F | |
Pair 3 | C105T | 0.00 | 1.00 | 1.00 | < 0.001 | PreS2A39V |
Pair 4 | C1826T&A1827C | 0.00 | 0.40 | 0.40 | 0.009 | PrecH5S;xT152P |
Pair 5 | C2366A | 0.00 | 0.50 | 0.50 | 0.004 | cP156T |
Pair 6 | T3116C | 0.00 | 0.94 | 0.94 | < 0.001 | PreS1V90A |
Pair 7 | T2708G | 0.00 | 0.95 | 0.95 | < 0.001 | non |
Pair 8 | G648C | 0.00 | 1.00 | 1.00 | < 0.001 | sW165S |
C732T | 0.00 | 0.38 | 0.38 | 0.016 | sS193L | |
Pair 9 | C1T | 0.50 | 0.00 | − 0.50 | 0.001 | non |
G20A | 0.00 | 1.00 | 1.00 | < 0.001 | PreS2A11T | |
A616G | 0.43 | 0.00 | − 0.43 | 0.003 | rtI163V | |
T999A | 0.36 | 1.00 | 0.64 | < 0.001 | non | |
C1913A | 0.50 | 0.00 | − 0.50 | 0.001 | cP5T | |
A2159G | 0.50 | 0.00 | − 0.50 | 0.001 | cS87G | |
A2189C | 0.50 | 0.00 | − 0.50 | 0.001 | cI97L | |
Pair 10 | C26A | 0.29 | 0.00 | − 0.29 | 0.024 | PreS2L13I |
T39A | 0.00 | 0.95 | 0.95 | < 0.001 | PreS2V17E | |
G1386A | 0.50 | 1.00 | 0.50 | 0.001 | xV5M | |
C2660T | 0.29 | 1.00 | 0.71 | < 0.001 | non | |
Pair 11 | T2576C | 0.00 | 1.00 | 1.00 | < 0.001 | non |