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Fig. 1 | Virology Journal

Fig. 1

From: The dynamic changes of HBV quasispecies diversity in infancy after immunoprophylaxis failure: a prospective cohort study

Fig. 1

Comparative analysis of HBV quasispecies characteristics during MTCT. The quasispecies complexity, mutation frequency and genetic distance were analyzed between mothers and their paired 7-month-old infants at nucleotide level (A, B and C) and amino acid level (D, E and F), respectively. The comparison of synonymous substitution rate (dS) (G) and non-synonymous substitution rate (dN) (H). *represents P < 0.05. **represents P < 0.01. “nt” represents the nucleotide level. “aa” represents the amino acid level. NTCP-BD: sodium taurocholate cotransporting polypetide binding domain. MHR: major hydrophilic region. Quasispecies complexity was measured using normalized Shannon entropy (Sn). Genetic distance was calculated at the nucleotide level under Tamura 3-parameter method and at the amino acid level under Jones–Taylor–Thornton matrix-based method. dS and dN were calculated under modified Nei–Gojobori model with Jukes–Cantor correction

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