Hepatitis B seroconversion revisited: new insights into the natural history of acute hepatitis B virus (HBV) infection from quantitative and highly sensitive assays and novel biomarkers

Table 3 Timing of antibody detection

Panel	Days relative to HBV DNA peak
Panel	Anti-HBc IgM First positive	Anti-HBc IgM Last positive	Anti-HBc (total) First positive	Anti-HBe First positive	Anti-HBs ≥ 10 mIU/ml
26022-14518	+ 7	+ 90	+ 2	+ 19	+ 19
13867-3482	+ 36	+ 101	+ 16	+ 14	+ 36
1807-3463	− 5	+ 111	− 13	+ 83	+ 147
43527-3453	+ 7	+ 245	+ 7	+ 317	+ 317
0994-3457	+ 20	+ 180	− 9	NA*	NA*

^*Not applicable (NA). This seroconverter developed persistent infection. Anti-HBe and anti-HBs were negative at the last follow-up sample 272 days after the HBV DNA peak. Minus sign ( −) indicates time before the HBV DNA peak; plus sign ( +) indicates time after the HBV DNA peak

ISSN: 1743-422X