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Fig. 1 | Virology Journal

Fig. 1

From: Hepatitis B seroconversion revisited: new insights into the natural history of acute hepatitis B virus (HBV) infection from quantitative and highly sensitive assays and novel biomarkers

Fig. 1

Serological and molecular assay profiles for three seroconversion panels with HBsAg positivity  less than 6 months and resolution of infection with development of anti-HBs ≥ 10 mIU/ml (26022-14518, 13867-3482, 1807-3463). For comparison purposes, all panels are synchronized relative to the peak HBV DNA level (set at Day 0). For graphing purposes, HBV DNA results detected below the LLOQ (10 IU/ml) were assigned the value of 1.0 IU/ml; undetectable HBV DNA was assigned a value of 0.1 IU/ml. HBV pgRNA results (one-tenth scale) detected below the LLOQ (44.7 U/ml) were assigned the value of 2 U/ml; undetectable pgRNA was assigned the value of 1 U/ml. HBcrAg values below the measuring range of the assay were assigned the value of 1 U/ml. Results are considered reactive as follows: Quantitative HBsAg ≥ 0.05 IU/ml, HBsAgNx S/CO ≥ 1.0, Quantitative HBeAg ≥ 0.28 IU/ml, anti-HBs ≥ 10 mIU/ml. HBV pgRNA results for panels 13867-3482 and 1807-3463 were reported elsewhere [8]

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Virology Journal

ISSN: 1743-422X