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Table 1 Classification and clinical symptoms of PeV-A

From: Development of a real-time RT-PCR assay for the detection of pan-human parechoviruses

Genotype of PeV-A

Clinical symptoms

PeV-A1

Mainly gastrointestinal tract symptoms (diarrhea and emesis) and respiratory tract symptoms (cough, wheezing, rhinorrhea, tachypnea and herpangina), followed by fever, rash, meningitis, encephalitis and acute flaccid paralysis

PeV-A3

Mainly neonatal fever, meningitis, encephalitis and neonatal sepsis-like disease, followed by gastrointestinal tract symptoms (diarrhea and emesis), respiratory tract symptoms (cough, wheezing, rhinorrhea, tachypnea and herpangina), rash and acute flaccid paralysis

PeV-A4

Mainly gastrointestinal tract symptoms (diarrhea and emesis) and respiratory tract symptoms (cough, wheezing, rhinorrhea, tachypnea and herpangina), followed by Neonatal fever, meningitis and encephalitis

PeV-A6

Gastrointestinal tract symptoms (diarrhea and emesis), respiratory tract symptoms (cough, wheezing, rhinorrhea, tachypnea and herpangina)

PeV-A2, 5, 8, 10

Gastrointestinal tract symptoms (diarrhea and emesis)

PeV-A7, 9, 11–19

Unknown