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Table 1 Identification of HPV16 variants in HNSCC in the literature (PubMed 2000–2020)

From: Exploring the roles of HPV16 variants in head and neck squamous cell carcinoma: current challenges and opportunities

Year publication

Reference

Country

Mean age patients (yrs)

Gender (% male)

Consumption (% active)

Samples

Total cases (n)

Total cases HPV detected %(n)

Total cases HPV16 detected %(n)

Total isolates for HPV sequencing

Genome region location

Amplicon size (pb)

Sequencing

2000

[48]

USA

63

no data available

87%

Fresh tissue

253

24% (62)

90% (56)

52

E6

455

Sanger

2004

[49]

Germany

no data available

no data available

no data available

FF/PE

24

100% (24)

100% (24)

21

E6 and E7

793

Sanger

2007

[50]

Italy

63

74%

67%

Fresh tissue FF/PE

115

18% (21)

67% (14/21)

13

L1

150

Sanger

2008

[51]

USA

57

77%

76%

Oral rinse FF/PE

135

32% (44)

100% (44/44)

19

E6

609

Sanger

2009

[52]

Japan

64

86%

79%

Fresh tissue

77

10% (8)

100% (8/8)

8

E6

323

Sanger

2013

[53]

Brazil

59

100%

50%

FF/PE

4

100% (4)

100% (4/4)

4

E6

no data available

Sanger

2015

[54]

Italy

65

88%

63%

FF/PE

24

100% (10)

100% (10/10)

10

E6

no data available

Sanger

2016

[55]

USA

60

86%

No data available

FF/PE

205

18% (36)

70% (25)

21

LCR

193

Sanger

2020

[56]

Iran

56

58%

No data available

FF/PE

108

23% (25)

16% (17)

13

E6

no data available

Sanger

  1. E6 Early gene 6; E7 early gene 7; LCR long control region; L1 late gene 1; FF/PE Formalin fixed Paraffin embedded