Fig. 6
From: Neutralization of interleukin-38 exacerbates coxsackievirus B3-induced acute myocarditis in mice
Neutralization of IL-38 reduced IFN-γ production, increased IL-17, TNF-α, and IL-6 levels, and promoted CVB3 replication. Cardiac mRNA expression levels of IFN-γ, IL-17, TNF-α, and IL-6 were detected by RT-qPCR, and serum protein levels of these cytokines were measured by ELISA in the Sham, PBS, IL-38N, and IgG groups. A–D IFN-γ, IL-17, TNF-α, and IL-6, respectively. E Levels of cardiac CVB3 RNA in different groups. F Levels of cardiac CVB3 titers in different groups. **P < 0.01, compared to Sham group; #P < 0.05, ##P < 0.01, compared to IgG group. Data are expressed as mean ± SD