Fig. 1
From: Anti-viral and pro-inflammatory functions of Toll-like receptors during gamma-herpesvirus infections
Summary of potential functions of TLR signaling in γ-herpesvirus infection. TLRs contribute to anti-viral responses against γ-herpesviruses, and their expression is induced in some situations, presumably as a result of anti-viral signaling (grey arrows). However, γ-herpesviruses also reduce expression and signaling of TLRs as an immune evasion strategy (light blue arrow). In addition, TLRs modulate γ-herpesvirus-caused diseases through their effect on inflammation (yellow arrows). Moreover, TLR activation can also reactivate the lytic cycle of γ-herpesviruses in latently infected cells (purple arrows)