Fig. 2
From: Modulation of host cell signaling during cytomegalovirus latency and reactivation
Regulation of receptor signaling induced by viral glycoproteins is required for HCMV latency establishment. During HCMV entry in myeloid cells, glycoprotein complexes engage cellular receptors, including EGFR, integrins, and TLR2, stimulating a complex network of signaling pathways that generates an environment necessary for the establishment of HCMV latency within the myeloid compartment. However, many of the same signaling pathways also promote MIEP activity, and thus must be “fine-tuned” to ensure the MIEP remains inactive. Evidence indicates that viral factors carried by the incoming virion, such as US28, actively regulate virus-mediated cellular pathways to promote the establishment of latency