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Fig. 6 | Virology Journal

Fig. 6

From: GATA binding protein 4 promotes the expression and transcription of hepatitis B virus by facilitating hepatocyte nuclear factor 4 alpha in vitro

Fig. 6

Stimulating HNF4α alleviates the inhibitory effect of siGATA4 on HBV in HepG2.2.15 cells. HepG2.2.15 cells were treated with benfluorex hydrochloride (Final concentration was 1 nM), a specific stimulator of HNF4α, for 48 h after siGATA4 for 24 h. a Chemical structure of the HNF4α specific stimulator, benfluorex hydrochloride (JP-992 hydrochloride). b Relative mRNA of GATA4 detected by RT-qPCR. NS, P > 0.05 vs. control of siGATA4. c HBsAg levels in the culture medium measured via ELISA kit assay. d Relative levels of HBV 3.5 kb pgRNA and total RNA detected via RT-qPCR, β-actin was used as the internal control

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Virology Journal

ISSN: 1743-422X