Fig. 4
From: Complex structural variations in non-human primate hepatitis B virus
Polymorphic structural variations (SVs) in human and non-human primate (NHP) HBVs in the pre-S1 region, and complex SVs observed in Bassi strain. Unique polymorphic SVs observed in human and NHP HBVs were analyzed in a previous study [18] and multiple alignment was created using woolly monkey HBV (WMHBV) as a reference. In addition, Bassi strain specific complex SVs observed in the pre-S1 region were shown. Segment A, B, and D, are conserved regions. Insertions X, Y, and Z are polymorphic SVs, and are further divided into X1-X3, Y1-Y3, and Z1-Z4, respectively [18]. (Del) shows deletion pattern minor variants (deletion of segment B and insertion X) observed only in human HBV/A and HBV/C. Bassi strain was highlighted in yellow. HBV/A, hepatitis B virus genotype A; Del, deletion; OuHBV, orangutan HBV; ChHBV, chimpanzee HBV, GoHBV, gorilla HBV; GiHBV, gibbon HBV