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Table 3 Factors associated with transmission within clusters

From: Transmitted drug resistance and transmission clusters among HIV-1 treatment-naïve patients in Guangdong, China: a cross-sectional study

Variable Number Persons in TC, N (%) Crude OR (95% CI) P-value Adjusted OR(95% CI) P-value
Total 2368      
Age (years)       
< 35 1097 527 (48.0) 1.000   1.000  
35–49 737 292 (39.6) 0.710 (0.587–0.858) < 0.001 0.857(0.661–1.111) 0.244
≥ 50 534 247 (46.3) 0.931 (0.757–1.145) 0.498   
Marital status       
Unmarried 1096 520 (47.4) 1.000   1.000  
Married 875 382 (43.7) 0.858 (0.718–1.026) 0.940   
Divorce or widow 289 118 (40.8) 0.764 (0.588–0.994) 0.045 0.811(0.569–1.155) 0.246
Unknown 108 46 (42.6) 0.822 (0.551–1.225) 0.336   
Education       
Primary and below 330 134 (40.6) 1.000   1.000  
Junior high school 823 355 (43.1) 1.110 (0.856–1.438) 0.432   
Senior high school 551 259 (47.0) 1.297 (0.984–1.710) 0.065   
College and above 586 286 (48.8) 1.394 (1.061–1.832) 0.017 0.997(0.697–1.424) 0.986
Unknown 78 32 (41.0) 1.018 (0.616–1.681) 0.946   
Ethnicity       
Han 2202 1000 (45.4) 1.000    
Ethnic minorities 88 34 (38.6) 0.757 (0.489–1.172) 0.212   
Unknown 78 32 (41.0) 0.836 (0.528–1.323) 0.445   
Route of infection       
Heterosexual intercourse 1004 408 (40.6) 1.000   1.000  
Homosexual intercourse 1107 563 (50.9) 1.512 (1.272–1.796) < 0.001 1.451(1.156–1.821) 0.001
Intravenous drug use 80 16 (20.0) 0.365 (0.208–0.641) < 0.001 0.266(0.144–0.493) < 0.001
Others 177 79 (44.6) 1.178 (0.853–1.625) 0.320   
CD4+ T cell count(cells/mm3)       
< 200 895 358 (40.0) 1.000   1.000  
200–499 1220 598 (49.0) 1.442 (1.211–1.717) < 0.001 1.339 (1.095–1.636) 0.004
≥ 500 253 110 (43.5) 1.154 (0.870–1.530) 0.320   
Genotype       
CRF01_AE 842 305 (36.2) 1.000   1.000  
CRF07_BC 850 560 (65.9) 3.400 (2.785–4.151) < 0.001 3.435 (2.789–4.232) < 0.001
CRF08_BC 66 12 (18.2) 0.391 (0.206–0.743) 0.004 0.488 (0.252–0.947) 0.034
CRF55_01B 244 145 (59.4) 2.579 (1.926–3.452) < 0.001 2.498 (1.850–3.372) < 0.001
CRF59_01B 53 22 (41.5) 1.249 (0.711–2.197) 0.439   
Subtype B 70 22 (31.4) 0.807 (0.478–1.363) 0.422   
Other 243 0 (0.0)    
Drug resistance       
Yes 52 15 (28.8) 1.000   1.000  
No 2316 1051 (45.4) 2.049 (1.119–3.755) 0.020 1.709 (0.884–3.302) 0.111
  1. TC, transmission cluster; OR, odd ration; CI, confidence interval; MSM, men who have sex with men; HET, heterosexual; IDU, intravenous drug use; CRF, circulating recombinant form