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Table 3 Factors associated with transmission within clusters

From: Transmitted drug resistance and transmission clusters among HIV-1 treatment-naïve patients in Guangdong, China: a cross-sectional study

Variable

Number

Persons in TC, N (%)

Crude OR (95% CI)

P-value

Adjusted OR(95% CI)

P-value

Total

2368

     

Age (years)

      

< 35

1097

527 (48.0)

1.000

 

1.000

 

35–49

737

292 (39.6)

0.710 (0.587–0.858)

< 0.001

0.857(0.661–1.111)

0.244

≥ 50

534

247 (46.3)

0.931 (0.757–1.145)

0.498

  

Marital status

      

Unmarried

1096

520 (47.4)

1.000

 

1.000

 

Married

875

382 (43.7)

0.858 (0.718–1.026)

0.940

  

Divorce or widow

289

118 (40.8)

0.764 (0.588–0.994)

0.045

0.811(0.569–1.155)

0.246

Unknown

108

46 (42.6)

0.822 (0.551–1.225)

0.336

  

Education

      

Primary and below

330

134 (40.6)

1.000

 

1.000

 

Junior high school

823

355 (43.1)

1.110 (0.856–1.438)

0.432

  

Senior high school

551

259 (47.0)

1.297 (0.984–1.710)

0.065

  

College and above

586

286 (48.8)

1.394 (1.061–1.832)

0.017

0.997(0.697–1.424)

0.986

Unknown

78

32 (41.0)

1.018 (0.616–1.681)

0.946

  

Ethnicity

      

Han

2202

1000 (45.4)

1.000

   

Ethnic minorities

88

34 (38.6)

0.757 (0.489–1.172)

0.212

  

Unknown

78

32 (41.0)

0.836 (0.528–1.323)

0.445

  

Route of infection

      

Heterosexual intercourse

1004

408 (40.6)

1.000

 

1.000

 

Homosexual intercourse

1107

563 (50.9)

1.512 (1.272–1.796)

< 0.001

1.451(1.156–1.821)

0.001

Intravenous drug use

80

16 (20.0)

0.365 (0.208–0.641)

< 0.001

0.266(0.144–0.493)

< 0.001

Others

177

79 (44.6)

1.178 (0.853–1.625)

0.320

  

CD4+ T cell count(cells/mm3)

      

< 200

895

358 (40.0)

1.000

 

1.000

 

200–499

1220

598 (49.0)

1.442 (1.211–1.717)

< 0.001

1.339 (1.095–1.636)

0.004

≥ 500

253

110 (43.5)

1.154 (0.870–1.530)

0.320

  

Genotype

      

CRF01_AE

842

305 (36.2)

1.000

 

1.000

 

CRF07_BC

850

560 (65.9)

3.400 (2.785–4.151)

< 0.001

3.435 (2.789–4.232)

< 0.001

CRF08_BC

66

12 (18.2)

0.391 (0.206–0.743)

0.004

0.488 (0.252–0.947)

0.034

CRF55_01B

244

145 (59.4)

2.579 (1.926–3.452)

< 0.001

2.498 (1.850–3.372)

< 0.001

CRF59_01B

53

22 (41.5)

1.249 (0.711–2.197)

0.439

  

Subtype B

70

22 (31.4)

0.807 (0.478–1.363)

0.422

  

Other

243

0 (0.0)

   

Drug resistance

      

Yes

52

15 (28.8)

1.000

 

1.000

 

No

2316

1051 (45.4)

2.049 (1.119–3.755)

0.020

1.709 (0.884–3.302)

0.111

  1. TC, transmission cluster; OR, odd ration; CI, confidence interval; MSM, men who have sex with men; HET, heterosexual; IDU, intravenous drug use; CRF, circulating recombinant form