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Table 3 Characteristic mutations detected in circulating SARS-CoV-2 clades

From: Evolutionary trajectory of SARS-CoV-2 and emerging variants

Clade Characteristic mutations References
L Reference Genome NC_045512.2 [94, 319]
V Nsp6: L37F
ORF3a: G251V
[95, 123, 129, 284]
S Nsp4: S76S
ORF8: L84S
[96, 285]
G 5’ UTR: C241T *
Nsp3: F106F
Nsp12: P323L
S: D614G
[104, 116, 117]
GH 5’ UTR: C241T *
Nsp3: F106F
Nsp12: P323L
S: D614G
ORF3a: Q57H
[121, 146]
GR 5’ UTR: C241T *
Nsp3: F106F
Nsp12: P323L
S: D614G
N: R203K
N: G204R
[123]
GV 5’ UTR: C241T *
Nsp3: F106F
Nsp12: P323L
S: A222V
S: D614G
[97, 150]
GRY 5’ UTR: C241T *
Nsp3: F106F
Nsp12: P323L
S: H69del
S: V70del
S: Y144del
S: N501Y
S: D614G
N: R203K
N: G204R
[89, 146]
O Variants without mutations characteristic of other clades [93, 94]
  1. Characteristic mutations for SARS-CoV-2 clades at the amino acid or nucleotide (*) levels