In vitro antiviral activity of peptide-rich extracts from seven Nigerian plants against three non-polio enterovirus species C serotypes

Table 2 Antiviral Activity of crude aqueous fraction and partially purified peptide fractions on three NPESC members

Extract	CC₅₀ (µg/mL)	CV-A13		CV-A20		EV-C99
Extract	CC₅₀ (µg/mL)	IC₅₀ (µg/mL)	SI	IC₅₀ (µg/mL)	SI	IC₅₀ (µg/mL)	SI
ABp	167.2	33.31	5.0	NA	NA	NA	NA
ACc	24.3	NA	NA	2.67	9.1	1.64	14.8
ACp	20.5	NA	NA	1.09	18.8	1.18	17.3
ICc	109.8	NA	NA	1.75	62.9	1.85	59.5
ICp	19.7	NA	NA	0.54	36.4	0.54	36.8
EHic	81.6	2.81	29.0	1.65	49.3	0.80	102.5
EHip	159.0	0.94	169.0	1.96	81.0	0.53	301.7
EHuc	167.5	17.28	9.7	19.57	8.6	9.45	17.7
EHup	169.0	20.94	8.1	5.47	30.9	5.30	31.9
EGc	33.2	1.969	16.8	NA	NA	0.644	51.6
EGp	39.1	3.203	12.2	1.663	23.5	0.531	73.6
PAp	68.0	NA	NA	1.11	61.5	0.59	116.3

c—crude aqueous fraction; p—partially purified peptide fraction; NA—not active; SI—selective index; CC50—50% cytotoxic concentration; IC50—50% inhibitory concentration; CVA13—Coxsackievirus A13; CVA20—Coxsackievirus A20; EVC99—Enterovirus C99

ISSN: 1743-422X