Lopinavir–ritonavir | IFN-α | Arbidol | Ribavirin | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Total (n = 403) | Yes (n = 335) | No (n = 68) | p-value | Yes (n = 341) | No (n = 62) | p-value |
Yes (n = 151) |
No (n = 252) | p-value |
Yes (n = 112) |
No (n = 291) | p-value | |
Age (yrs, median, IQR) | 48[35, 60] | 49[35, 61] | 45[35, 57] | 0.42 | 49[35, 61] | 43[34, 56] | 0.071 | 46[33, 61] | 49[36, 60] | 0.23 | 56[40, 64] | 46[32, 57] | 6.1E−07 |
Sex | M:203 (50.4%) F:200 (49.6%) | M:169 (50.4%) F:166 (49.6%) | M:34 (50.0%) F:34 (50.0%) | 0.95 | M:169 (49.6%) F:172 (50.4%) | M:34 (54.8%) F:28 (45.2%) | 0.44 | M:84 (55.6%) F:67 (44.4%) | M:119 (47.2%) F:133 (52.8%) | 0.10 | M:65 (58.0%) F:47 (42.0%) | M:138 (47.4%) F:153 (52.6%) | 0.056 |
Fever #No. of cases (%) | Y:282 (70.0%) N:121 (30.0%) | Y:247 (73.7%) N:88 (26.3%) | Y:35 (51.5%) N:33 (48.5%) | 2.4E−04 | Y:254 (74.5%) N:87 (25.5%) | Y:28 (45.2%) N:34 (54.8%) | 2.8E−06 | Y:100 (66.2%) N:51 (33.8%) | Y:182 (72.2%) N:70 (27.8%) | 0.21 | Y:85 (75.9%) N:27 (24.1%) | Y:197 (67.7%) N:94 (32.3%) | 0.11 |
Cough | Y:214 (53.1%) N:189 (46.9%) | Y:182 (54.3%) N:153 (45.7%) | Y:32 (47.1%) N:36 (52.9%) | 0.27 | Y:179 (52.5%) N:162 (47.5%) | Y:35 (56.5%) N:27 (43.5%) | 0.57 | Y:73 (48.3%) N:78 (51.7%) | Y:141 (56.0%) N:111 (44.0%) | 0.14 | Y:72 (64.3%) N:40 (35.7%) | Y:142 (48.8%) N:149 (51.2%) | 0.005 |
Fatigue | Y:76 (18.9%) N:327 (81.1%) | Y:61 (18.2%) N:274 (81.8%) | Y:15 (22.1%) N:53 (77.9%) | 0.46 | Y:70 (20.5%) N:271 (79.5%) | Y:6 (9.7%) N:56 (90.3%) | 0.045 | Y:20 (13.2%) N:131 (86.8%) | Y:56 (22.2%) N:196 (77.8%) | 0.026 | Y:27 (24.1%) N:85 (75.9%) | Y:49 (16.8%) N:242 (83.2%) | 0.095 |
Running nose | Y:44 (10.9%) N:359 (89.1%) | Y:32 (9.6%) N:303 (90.4%) | Y:12 (17.6%) N:56 (82.4%) | 0.051 | Y:37 (10.9%) N:304 (89.1%) | Y:7 (11.3%) N:55 (88.7%) | 0.92 | Y:20 (13.2%) N:131 (86.8%) | Y:24 (9.5%) N:228 (90.5%) | 0.25 | Y:16 (14.3%) N:96 (85.7%) | Y:28 (9.6%) N:263 (90.4%) | 0.18 |
Headache | Y:68 (16.9%) N:335 (83.1%) | Y:54 (16.1%) N:281 (83.9%) | Y:14 (20.6%) N:54 (79.4%) | 0.37 | Y:56 (16.4%) N:285 (83.6%) | Y:12 (19.4%) N:50 (80.6%) | 0.57 | Y:27 (17.9%) N:124 (82.1%) | Y:41 (16.3%) N:211 (83.7%) | 0.68 | Y:19 (17.0%) N:93 (83.0%) | Y:49 (16.8%) N:242 (83.2%) | 0.97 |
Diarrhea | Y:39 (9.7%) N:364 (90.3%) | Y:35 (10.4%) N:300 (89.6%) | Y:4 (5.9%) N:64 (94.1%) | 0.25 | Y:33 (9.7%) N:308 (90.3%) | Y:6 (9.7%) N:56 (90.3%) | 1.00 | Y:14 (9.3%) N:137 (90.7%) | Y:25 (9.9%) N:227 (90.1%) | 0.83 | Y:13 (11.6%) N:99 (88.4%) | Y:26 (8.9%) N:265 (91.1%) | 0.42 |
Nausea | Y:13 (3.2%) N:390 (96.8%) | Y:11 (3.3%) N:324 (96.7%) | Y:2 (2.9%) N:66 (97.1%) | 0.88 | Y:11 (3.2%) N:330 (96.8%) | Y:2 (3.2%) N:60 (96.8%) | 1.00 | Y:4 (2.6%) N:147 (97.4%) | Y:9 (3.6%) N:243 (96.4%) | 0.61 | Y:6 (5.4%) N:106 (94.6%) | Y:7 (2.4%) N:284 (97.6%) | 0.13 |
Respiratory symptom | Y:18 (4.5%) N:385 (95.5%) | Y:16 (4.8%) N:319 (95.2%) | Y:2 (2.9%) N:66 (97.1%) | 0.51 | Y:15 (4.4%) N:326 (95.6%) | Y:3 (4.8%) N:59 (95.2%) | 0.88 | Y:6 (4.0%) N:145 (96.0%) | Y:12 (4.8%) N:240 (95.2%) | 0.71 | Y:7 (6.2%) N:105 (93.8%) | Y:11 (3.8%) N:280 (96.2%) | 0.28 |
Pharyngalgia | Y:71 (17.6%) N:332 (82.4%) | Y:62 (18.5%) N:273 (81.5%) | Y:9 (13.2%) N:59 (86.8%) | 0.30 | Y:61 (17.9%) N:280 (82.1%) | Y:10 (16.1%) N:52 (83.9%) | 0.74 | Y:29 (19.2%) N:122 (80.8%) | Y:42 (16.7%) N:210 (83.3%) | 0.52 | Y:18 (16.1%) N:94 (83.9%) | Y:53 (18.2%) N:238 (81.8%) | 0.61 |
Myalgia | Y:54 (13.4%) N:349 (86.6%) | Y:51 (15.2%) N:284 (84.8%) | Y:3 (4.4%) N:65 (95.6%) | 0.017 | Y:49 (14.4%) N:292 (85.6%) | Y:5 (8.1%) N:57 (91.9%) | 0.18 | Y:22 (14.6%) N:129 (85.4%) | Y:32 (12.7%) N:220 (87.3%) | 0.60 | Y:22 (19.6%) N:90 (80.4%) | Y:32 (11.0%) N:259 (89.0%) | 0.022 |
Chest symptom | Y:39 (9.7%) N:364 (90.3%) | Y:33 (9.9%) N:302 (90.1%) | Y:6 (8.8%) N:62 (91.2%) | 0.79 | Y:33 (9.7%) N:308 (90.3%) | Y:6 (9.7%) N:56 (90.3%) | 1.00 | Y:11 (7.3%) N:140 (92.7%) | Y:28 (11.1%) N:224 (88.9%) | 0.21 | Y:16 (14.3%) N:96 (85.7%) | Y:23 (7.9%) N:268 (92.1%) | 0.052 |
Hypertension history | Y:61 (15.1%) N:342 (84.9%) | Y:52 (15.5%) N:283 (84.5%) | Y:9 (13.2%) N:59 (86.8%) | 0.63 | Y:51 (15.0%) N:290 (85.0%) | Y:10 (16.1%) N:52 (83.9%) | 0.81 | Y:25 (16.6%) N:126 (83.4%) | Y:36 (14.3%) N:216 (85.7%) | 0.54 | Y:21 (18.8%) N:91 (81.2%) | Y:40 (13.7%) N:251 (86.3%) | 0.21 |
Cardiovascular history | Y:19 (4.7%) N:384 (95.3%) | Y:16 (4.8%) N:319 (95.2%) | Y:3 (4.4%) N:65 (95.6%) | 0.89 | Y:16 (4.7%) N:325 (95.3%) | Y:3 (4.8%) N:59 (95.2%) | 0.96 | Y:8 (5.3%) N:143 (94.7%) | Y:11 (4.4%) N:241 (95.6%) | 0.67 | Y:7 (6.2%) N:105 (93.8%) | Y:12 (4.1%) N:279 (95.9%) | 0.37 |
Respiratory History | Y:21 (5.2%) N:382 (94.8%) | Y:20 (6.0%) N:315 (94.0%) | Y:1 (1.5%) N:67 (98.5%) | 0.13 | Y:16 (4.7%) N:325 (95.3%) | Y:5 (8.1%) N:57 (91.9%) | 0.27 | Y:7 (4.6%) N:144 (95.4%) | Y:14 (5.6%) N:238 (94.4%) | 0.69 | Y:12 (10.7%) N:100 (89.3%) | Y:9 (3.1%) N:282 (96.9%) | 0.002 |
Diabetes history | Y:19 (4.7%) N:384 (95.3%) | Y:15 (4.5%) N:320 (95.5%) | Y:4 (5.9%) N:64 (94.1%) | 0.62 | Y:17 (5.0%) N:324 (95.0%) | Y:2 (3.2%) N:60 (96.8%) | 0.55 | Y:4 (2.6%) N:147 (97.4%) | Y:15 (6.0%) N:237 (94.0%) | 0.13 | Y:6 (5.4%) N:106 (94.6%) | Y:13 (4.5%) N:278 (95.5%) | 0.71 |
Infection disease history | Y:17 (4.2%) N:386 (95.8%) | Y:16 (4.8%) N:319 (95.2%) | Y:1 (1.5%) N:67 (98.5%) | 0.22 | Y:14 (4.1%) N:327 (95.9%) | Y:3 (4.8%) N:59 (95.2%) | 0.79 | Y:5 (3.3%) N:146 (96.7%) | Y:12 (4.8%) N:240 (95.2%) | 0.48 | Y:5 (4.5%) N:107 (95.5%) | Y:12 (4.1%) N:279 (95.9%) | 0.88 |
Allergic history | Y:38 (9.4%) N:365 (90.6%) | Y:33 (9.9%) N:302 (90.1%) | Y:5(7.4%) N:63 ( (92.6%) | 0.52 | Y:34 (10.0%) N:307 (90.0%) | Y:4 (6.5%) N:58 (93.5%) | 0.38 | Y:18 (11.9%) N:133 (88.1%) | Y:20 (7.9%) N:232 (92.1%) | 0.19 | Y:10 (8.9%) N:102 (91.1%) | Y:28 (9.6%) N:263 (90.4%) | 0.83 |
Surgery history | Y:76 (18.9%) N:327 (81.1%) | Y:68 (20.3%) N:267 (79.7%) | Y:8 (11.8%) N:60 (88.2%) | 0.10 | Y:60 (17.6%) N:281 (82.4%) | Y:16 (25.8%) N:46 (74.2%) | 0.13 | Y:33 (21.9%) N:118 (78.1%) | Y:43 (17.1%) N:209 (82.9%) | 0.24 | Y:18 (16.1%) N:94 (83.9%) | Y:58 (19.9%) N:233 (80.1%) | 0.38 |