Characteristics | Results |
---|---|
Number of pregnancy cases | n = 17 (17 out of 1,106; 1.54%) |
Age (years) | 32 (range 17–41) |
Gravidity | G1: n = 9 (52.9%), G2: n = 5 (29.4%), G3: n = 3 (17.6%) |
Twin/Triplet pregnancy | n = 3 (17.6%) |
Gestational age | First trimester: n = 1 (5.9%), Second trimester: n = 2 (11.8%), Third trimester: n = 14 (82.4%) |
Clinical/laboratory presentations | |
Hyperbilirubinemia | n = 8 (47.1%) |
Elevation of AST or ALT > 100 U/L | n = 13 (76.5%) |
Liver function test (All 17 cases) | |
AST (U/L) | 143 (24–1,576) |
ALT (U/L) | 242 (19–1,708) |
ALP (U/L) | 196 (57–500) |
TB (mg/dL) | 2.04 (0.3–24.3) |
Diagnoses | |
Recent viral hepatitis | n = 4 (23.5%); HAV (n = 1), HBV (n = 2), HEV (n = 2) |
Acute fatty liver in pregnancy | n = 5 (29.4%); one was also diagnosed with syphilis |
Pre-eclampsia/HELLP | n = 3 (17.6%) |
Others | ATV/r induced hyperbilirubinemia (n = 1), chronic HT with UGIB (n = 1), acute/post-arrest hepatitis (n = 2), pregnancy with DFIU (n = 1) |
Pregnancy and fetal complications | |
Ectopic pregnancy/DFIU | n = 2 (11.8%) |
Threaten preterm labor/preterm labor | n = 3 (17.6%); from maternal HAV infection (n = 1), maternal HBV infection (n = 1) |
Low infant birth weight (< 2,500 g) | n = 10 (58.9%); from maternal HAV infection (n = 1), maternal HBV infection (n = 1), maternal HEV infection (n = 1) |
Timing of anti-HEV antibody test | Pre-partum: n = 7 (41.2%), Peri/Post-partum: n = 10 (58.9%) |
Results of anti-HEV antibody test | |
Positive anti-HEV IgG antibody | n = 7 (41.2%); two cases were also tested positive for anti-HEV IgM |
Positive anti-HEV IgM antibody | n = 2 (11.8%) |
Liver function test (HEV seropositive cases) | anti-HEV IgG + /IgM- (n = 5) | anti-HEV IgG + /IgM + (n = 2) |
---|---|---|
AST (U/L) | 143 (24–1576) | 80.5 (45–116) |
ALT (U/L) | 124 (19–1615) | 74 (32–116) |
ALP (U/L) | 183 (78–473) | 444 (388–500) |
TB (mg/dL) | 0.7 (0.3–24.3) | 7.95 (4.9–11) |