Fig. 3
From: The key amino acids of E protein involved in early flavivirus infection: viral entry
Modeled structure, domain architecture, special structure and mutation sites of envelope protein. Flavivirus E protein diagram representation crystal structure is shown above. Domain I is highlighted in red, domain II is highlighted in limon, domain III is highlighted in purpleblue, stem region is highlighted in gray and transmembrane region is highlighted in orange. Amino acids involved in the early infection process are colored in blue and shown as spheres. The special structure is highlighted in light gray. (A) Top view of the Envelope protein monomer structure, JEV (PDB: 5MV1) as the model template [53]. (B) Side view of the E dimer structure, ZIKV (PDB: 5IZ7) as the model template. (C) The interaction between H144 and H319 is indicated by dashed lines. (D) N154 glycosylation site. (E) DI-DIII hinge region. (F) α-helix in stem region