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Table 1 HCV infection status in relation to four S/Co ranges in four assays

From: A study based on four immunoassays: Hepatitis C virus antibody against different antigens may have unequal contributions to detection

Assays Groups S/Co ranges
< 1 1–2.5 2.5–4 > 4
Ortho ELISA Viremia (n) 0 1 0 263
% 0.0 0.4 0.0 99.6
Consistent (n) 0 47 34 142
% 0.0 21.1 15.2 63.7
Discrepant (n) 80 73 26 16
% 41.0 37.4 13.3 8.2
Murex ELISA Viremia (n) 0 22 29 213
% 0.0 8.3 11.0 80.7
Consistent (n) 0 29 21 173
% 0.0 13.0 9.4 77.6
Discrepant (n) 86 41 17 51
% 44.1 21.0 8.7 26.2
Architect CMIA Viremia (n) 0 0 2 262
% 0.0 0.0 0.8 99.2
Consistent (n) 0 70 20 133
% 0.0 31.4 9.0 59.6
Discrepant (n) 29 92 47 27
% 14.9 47.2 24.1 13.8
Elecsys ECLIA Viremia (n) 0 0 0 264
% 0.0 0.0 0.0 100.0
Consistent (n) 0 0 0 223
% 0.0 0.0 0.0 100.0
Discrepant (n) 152 2 3 38
% 77.9 1.0 1.5 19.5
  1. aIn each of the four assays, specimens were classified into three groups: (1) HCV RNA positive group (Viremia, n = 264); (2) HCV RNA negative, anti-HCV consistent group (Consistent, n = 223); (3) HCV RNA negative, anti-HCV discrepant group (Discrepant, n = 195). In each group, the specimens were further divided into four S/Co ranges with specific numbers and percentages. S/Co value < 1.0 was considered as anti-HCV negative while S/Co value > 4 was considered strongly anti-HCV positive