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Table 4 The viral load, levels of inflammatory markers and lymphocyte subsets of the study subjects according to disease severity of COVID-19 during hospitalization

From: Viral loads, lymphocyte subsets and cytokines in asymptomatic, mildly and critical symptomatic patients with SARS-CoV-2 infection: a retrospective study

Laboratory findings Disease severity of COVID-19 Statistic parameter
(mean ± SD) AS (n = 11) MS (n = 26) SCS (n = 11) F value P value
Ct values 29.9 ± 2.4 30.4 ± 1.9 31.5 ± 1.5 2.186 0.061
B cells (%) 15.0 ± 9.9 11.5 ± 7.0 4.0 ± 3.2 7.017 0.002**
NK cells (%) 9.8 ± 20.9 3.9 ± 2.9 3.4 ± 1.2 1.284 0.285
CD3 + T cells (%) 69.7 ± 9.9 62.7 ± 9.1 54.7 ± 13.9 5.640 0.007**
CD3 + CD4 + T cells (%) 37.5 ± 10.3 40.1 ± 7.9 31.6 ± 104 3.327 0.045*
CD3 + CD8 + T cells (%) 23.1 ± 6.3 24.2 ± 10.5 17.0 ± 5.6 5.315 0.008**
CD4 + /CD8 + ratio (%) 1.7 ± 1.3 2.3 ± 1.1 2.0 ± 0.9 1.219 0.305
IL2 (pg/mL) 5.4 ± 3.9 3.9 ± 3.6 6.7 ± 5.6 1.805 0.176
IL4 (pg/mL) 9.27 ± 20.9 3.9 ± 3.6 6.7 ± 5.6 1.335 0.273
IL5 (pg/mL) 6.7 ± 8.3 5.3 ± 5.6 5.8 ± 5.2 0.197 0.822
IL6 (pg/mL) 12.3 ± 18.4 6.1 ± 12.5 574.9 ± 1325.4 3.389 0.039*
IL8 (pg/mL) 132.5 ± 114.4 33.5 ± 43.7 869.7 ± 1927.2 3.374 0.043*
IL10 (pg/mL) 2.9 ± 1.1 2.7 ± 1.2 7.4 ± 7.5 6.525 0.003**
TNF-α (pg/mL) 30.9 ± 28.9 25.5 ± 38.0 15.2 ± 24.2 0.639 0.533
INF-α (pg/mL) 5.7 ± 9.3 4.7 ± 6.4 3.3 ± 0.8 0.380 0.686
INF-γ (pg/mL) 12.4 ± 24.0 19.2 ± 48.7 11.7 ± 8.7 0.211 0.810
  1. One‐way analysis of variance. Statistically significant, *P < 0. 05, **P < 0.001