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Table 1 Baseline characteristics of the subjects in study

From: Identification and characterization of lncRNA AP000253 in occult hepatitis B virus infection

  Discovery phase Validation phase
HCs (n = 10) OBI (n = 10) P HCs (n = 20) OBI (n = 64)a ASC (n = 20) CHB (n = 31)b P
Demographic characteristics
 Female (n, %) 1 (10.00) 2 (20.00) 0.53 6 (30.00) 22 (34.38) 7 (35.00) 10 (41.94) 0.98
 Age (years) 39.30 ± 11.68 42.80 ± 7.96 0.45 38.00 ± 7.94 42.86 ± 8.81 36.00 ± 7.48 43.11 ± 14.16 0.09
Serological characteristics
 ALT (U/L) 19.56 ± 7.63 22.70.67 ± 11.14 0.48 16.74 ± 6.41 18.99 ± 9.79 37.80 ± 8.23 219.94 ± 263.70 0.13
 HBsAg (S/CO, positive) 0.31 ± 0.30
0
0.12 ± 0.16
0
0.12 0.21 ± 0.25
0
0.16 ± 0.21
0
22.89 ± 9.91
20
272.28 ± 139.62
31
< 0.01c
 Anti-HBs (S/CO, positive) 7.00 ± 8.32
5
0.87 ± 0.72
3
0.04 8.24 ± 8.18
12
0.77 ± 1.21
7
0.21 ± 0.24
0
0.23 ± 0.72
0
< 0.01c
 HBeAg (S/CO, positive) 0.08 ± 0.03
0
0.07 ± 0.02
0
0.89 0.07 ± 0.01
0
0.05 ± 0.02
0
0.06 ± 0.01
0
38.91 ± 82.97
7
0.46c
 Anti-HBe (S/CO, positive) 1.60 ± 0.31
0
1.28 ± 0.47
2
0.11 1.88 ± 0.12
0
0.97 ± 0.40
8
0.24 ± 0.34
19
8.53 ± 30.90
24
< 0.01c
 Anti-HBc (S/CO, positive) 1.48 ± 0.47
1
0.71 ± 0.73
7
0.02 1.96 ± 0.40
0
0.45 ± 0.53
28
0.08 ± 0.07
20
11.03 ± 1.84
31
< 0.01c
 HBV-DNA (Ct) NA 34.89 ± 1.25 NA NA 35.86 ± 1.87 33.67 ± 3.01 23 ~ 2.88E + 8 < 0.01c
  1. OBI occult HBV infection, CHB chronic hepatitis B, ASC asymptomatic HBsAg carriers, HC healthy controls, HBsAg hepatitis B surface antigen, Anti-HBs antibody for HBsAg, HBeAg hepatitis B envelope antigen, Anti-HBe antibody for HBeAg, Anti-HBc antibody for hepatitis B core antigen, ALT alanine aminotransferase, Ct cycle threshold, NA not available
  2. aDue to limited volume, the results of Anti-HBs, HBeAg, Anti-HBe and Anti-HBc were only available for 34 OBI samples
  3. bHBsAg, Anti-HBs, HBeAg, Anti-HBe and Anti-HBc were measured with Anytest-2000 TRF detection system, and HBV DNA was detected with HBV DNA PCR-fluorescence quantitative diagnostic kit(KHB)
  4. cP value indicated the statistic differences between HCs, OBI and ASC groups