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Table 3 Comparison of laboratory results before and after the treatment between groups (Group 1: Early treatment with FPV and HQ, Group 2: Late treatment with FPV and HQ, Group 3: Treatment with only HQ)

From: Benefits of treatment with favipiravir in hospitalized patients for COVID-19: a retrospective observational case–control study

 

Compare groups

Mean difference

SE

p

95% CI

CRP

Group 2–Group 3

37.0

9.9

0.001

13.3–60.6

Group 1–Group 2

13.9

12.5

0.512

 − 15.6–43.7

Group 1–Group 3

50.9

10.2

 < 0.001

26.5–75.2

Lymphocyte

Group 2–Group 3

16.8

166.3

0.994

 − 425.0–391.4

Group 2–Group 1

253.0

129.8

0.131

 − 56.8–562.7

Group 3–Group 1

236.2

152.5

0.286

 − 143.7–616.1

D-Dimer

Group 2–Group 3

0.41

0.72

0.837

 − 1.34–2.16

Group 2–Group 1

0.83

0.58

0.333

 − 0.58–2.25

Group 3–Group 1

0.42

0.88

0.881

 − 1.68–2.53

AST

Group 2–Group 3

20.1

7.3

0.022

2.42–37.7

Group 1–Group 2

2.4

8.2

0.952

 − 17.1–22.0

Group 1–Group 3

22.5

5.5

 < 0.001

9.4–35.6

ALT

Group 2–Group 3

10.2

8.3

0.441

 − 9.8–30.3

Group 1–Group 2

3.9

8.3

0.887

 − 16.0–23.8

Group 1–Group 3

14.1

6.4

0.083

 − 1.5–29.8

Ferritin

Group 2–Group 3

240.2

90.0

0.030

20.2–460.2

Group 1–Group 2

119.1

151.3

0.712

 − 244.7–482.8

Group 1–Group 3

359.3

137.5

0.032

25.6–693.1

Cr

Group 3–Group 2

2.39

1.17

0.138

 − 0.67–5.44

Group 1–Group 2

0.25

0.39

0.804

 − 0.69–1.18

Group 3–Group 1

2.15

1.22

0.212

 − 0.98–5.27

  1. Statistically significant values are presented in bold. Tukey's test and Games Howell tests were preferred as posthoc tests
  2. ALT alanine aminotransferase; AST aspartate aminotransferases; CRP c-reactive protein; Cr Creatinin