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Table 1 Demographic data and clinical characteristics of patients in the IVIG and non-IVIG groups

From: Intravenous immunoglobulin-based adjuvant therapy for severe COVID-19: a single-center retrospective cohort study

Parameter

Total

n = 113

Non-IVIG

n = 66

IVIG

n = 47

P

Age

55.1 ± 14.2

55.3 ± 15.5

54.8 ± 12.4

0.865

Female

52 (46.0%)

32 (48.5%)

20 (42.6%)

0.533

Comorbidity

39 (34.5%)

23 (34.8%)

16 (34.0%)

0.929

Hypertension

26 (23.0%)

14 (21.2%)

12 (25.5%)

0.591

Diabetes

13 (11.5%)

6 (9.1%)

7 (14.9%)

0.341

Coronary heart disease

7 (6.2%)

7 (10.6%)

0 (0)

0.021

COPD

6 (5.3%)

5 (7.6%)

1 (2.1%)

0.203

Cerebrovascular disease

4 (3.5%)

4 (6.1%)

0 (0)

0.086

Onset time

7.0 (5.0–10.0)

7.0 (5.0–9.2)

7.0 (5.0–10.0)

0.268

Maximum body temperature

38.5 (37.8–39.0)

38.0 (37.5–38.8)

38.9 (38.2–39.0)

0.002

WBC

5.61 (4.09–8.04)

5.00 (3.68–6.79)

7.45 (4.73–9.42)

< 0.001

LYM

1.07 (0.72–1.51)

1.24 (0.90–1.75)

0.79 (0.62–1.21)

< 0.001

PLT

200.0 (153.0–256.0)

203.0 (149.8–252.2)

190.0 (159.0–257.0)

0.836

ALT

23.0 (16.5–37.2)

21.0 (14.2–29.2)

29.7 (18.0–47)

0.008

AST

21.0 (17.0–33.0)

20.6 (16.8–26.2)

22.0 (17.0–40.0)

0.287

Cr

78.1 ± 23.9

78.2 ± 24.3

78.8 ± 23.6

0.896

PT

44.6 ± 1.3

11.4 ± 1.2

11.9 ± 1.4

0.56

DD

192.0 (115.0–456.0)

182.5 (105.8–294.5)

216.0 (125.0–840.0)

0.249

GC

57 (50.4%)

18 (27.3%)

39 (83.0%)

< 0.001

  1. IVIG intravenous immunoglobulin, COPD chronic obstructive pulmonary disease, WBC white blood cell, LYM lymphocyte, PLT platelet, ALT alanine aminotransferase, AST aspartate aminotransferase, Cr serum creatinine, PT prothrombin time, DD d-dimer, GC Glucocorticoid