Table 2 Mutation record analysis of MERS-CoV strains identified in the current study
From: Sequence and phylogentic analysis of MERS-CoV in Saudi Arabia, 2012–2019
Gene | Mutation | Amino acid change | Positive/negative selection | Saudi MERS-CoV strains | |||
|---|---|---|---|---|---|---|---|
Hu-Dammam_1_2015 | Hu-Dammam_2_2015 | Hu-Madinah_4_2015 | Hu-Riyadh_11_2014 | ||||
ORF1a | C3442T | – | Positive | + | − | − | − |
ORF1a | C8518T | A2840V | Positive | + | + | + | + |
ORF1a | A8846G | – | Negative | − | − | + | − |
ORF1a | C8953T | S2985F | – | − | − | + | − |
ORF1b | C19075A | – | Negative | + | + | + | + |
Spike | T21569C | – | – | + | − | − | − |
Spike | T21713C | – | – | − | + | + | + |
Spike | C22169T | – | – | − | − | − | + |
Spike | T22337C | – | – | + | − | − | − |
Spike | C22349T | – | Negative | + | − | + | − |
Spike | G22427T | – | – | + | − | − | − |
Spike | T22895C | – | Negative | + | − | − | − |
Spike | T23406C | – | – | + | − | − | − |
Spike | T23504C | – | – | − | + | + | + |
Spike | C23570T | – | Negative | − | + | + | + |
Spike | C23648T | – | Negative | − | + | + | + |
Spike | T23714G | – | – | + | − | − | − |
Spike | C23756T | – | Negative | − | + | + | + |
Spike | C23804T | – | – | − | + | + | + |
ORF3 | C25580T | L8527F | – | − | + | + | + |
ORF3 | C25656T | A8552V | – | + | − | − | − |
ORF3 | A25768T | – | Negative | − | + | + | + |
ORF3 | C25788T | S8596L | Positive | − | + | + | + |
ORF4+b | T26109C | S8703T | – | − | + | + | + |
ORF4b | G26167C | M8723T | – | + | − | − | − |
ORF4b | C26216T | – | – | − | + | − | − |
ORF4b | C26518T | – | – | + | − | − | − |