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Table 2 Mutation record analysis of MERS-CoV strains identified in the current study

From: Sequence and phylogentic analysis of MERS-CoV in Saudi Arabia, 2012–2019

Gene Mutation Amino acid change Positive/negative selection Saudi MERS-CoV strains
Hu-Dammam_1_2015 Hu-Dammam_2_2015 Hu-Madinah_4_2015 Hu-Riyadh_11_2014
ORF1a C3442T Positive +
ORF1a C8518T A2840V Positive + + + +
ORF1a A8846G Negative +
ORF1a C8953T S2985F +
ORF1b C19075A Negative + + + +
Spike T21569C +
Spike T21713C + + +
Spike C22169T  + 
Spike T22337C  + 
Spike C22349T Negative  +   + 
Spike G22427T  + 
Spike T22895C Negative  + 
Spike T23406C  + 
Spike T23504C  +   +   + 
Spike C23570T Negative  +   +   + 
Spike C23648T Negative  +   +   + 
Spike T23714G  + 
Spike C23756T Negative  +   +   + 
Spike C23804T  +   +   + 
ORF3 C25580T L8527F  +   +   + 
ORF3 C25656T A8552V  + 
ORF3 A25768T Negative  +   +   + 
ORF3 C25788T S8596L Positive  +   +   + 
ORF4+b T26109C S8703T + + +
ORF4b G26167C M8723T +
ORF4b C26216T +
ORF4b C26518T +