Table 1 Demographics and baseline laboratory markers of mild and severe ill COVID-19 patients in Hefei Cohort
Mild (N = 54) | Severe (N = 28) | P | |
|---|---|---|---|
Gender = male (%) | 28 (51.9) | 23 (82.1) | 0.015 |
Smoke = yes (%) | 2 (3.7) | 0 (0.0) | 0.782 |
Cough = yes (%) | 42 (77.8) | 20 (71.4) | 0.716 |
Fever = yes (%) | 46 (85.2) | 22 (78.6) | 0.656 |
Comorbidity = yes (%) | 8 (14.8) | 16 (57.1) | < 0.001 |
Age | 40.00 (28.25–50.00) | 55.50 (44.75–65.75) | < 0.001 |
Blood routine test | |||
WBC (× 109/L) | 4.64 (4.04–5.64) | 6.52 (5.13–7.25) | 0.004 |
NEU% | 62.50 (51.38–71.40) | 80.50 (73.92–87.62) | < 0.001 |
NEU (× 109/L) | 2.69 (2.08–3.76) | 5.21 (3.93–6.37) | < 0.001 |
MONO% | 7.45 (5.55–8.57) | 5.60 (4.45–7.95) | 0.043 |
MONO (× 109/L) | 0.35 (0.26–0.45) | 0.34 (0.24–0.56) | 0.754 |
LYM% | 27.45 (21.10–37.72) | 12.90 (7.45–18.62) | < 0.001 |
LYM (× 109/L) | 1.29 (0.85–1.75) | 0.82 (0.49–1.09) | < 0.001 |
RBC (× 1012/L) | 4.62 (4.13–5.00) | 4.51 (4.37–4.78) | 0.685 |
Hemaglobin (g/L) | 140.00 (122.00–153.75) | 140.50 (129.00–144.50) | 0.591 |
Hematocrit (%) | 0.41 (0.37–0.46) | 0.42 (0.39–0.43) | 0.46 |
PLT (× 109/L) | 163.50 (135.50–224.25) | 162.00 (128.75–202.75) | 0.345 |
Coagulation test | |||
APTT (s) | 38.70 (35.23–43.63) | 35.80 (29.67–39.82) | 0.019 |
TT (s) | 13.90 (13.20–14.70) | 14.45 (13.85–14.95) | 0.045 |
Fibrinogen(g/L) | 2.73 (1.88–3.40) | 3.58 (3.19–4.31) | < 0.001 |
PT (s) | 14.45 (13.43–16.38) | 14.05 (13.28–14.95) | 0.177 |
D-dimer (µg/L) | 0.19 (0.08–0.28) | 0.45 (0.23–0.66) | < 0.001 |
Clinical chemistry test | |||
TBIL (µmol/L) | 14.20 (11.20–18.20) | 14.75 (9.78–20.23) | 0.728 |
DBIL (µmol/L) | 5.30 (4.40–6.40) | 5.80 (4.68–8.97) | 0.096 |
ALT (U/L) | 19.00 (14.00–35.00) | 29.00 (23.75–42.25) | 0.009 |
AST (U/L) | 24.00 (20.00–34.00) | 31.50 (23.00–39.50) | 0.023 |
GGT (U/L) | 22.00 (17.00–37.00) | 42.00 (27.75–64.50) | < 0.001 |
ALP (U/L) | 60.00 (48.00–71.00) | 60.00 (42.75–81.25) | 0.713 |
Total protein (g/L) | 72.90 (68.60–75.80) | 70.25 (66.75–73.45) | 0.13 |
Albumin (g/L) | 44.90 (42.10–48.20) | 38.15 (36.00–40.85) | < 0.001 |
Glucose (mmol/L) | 5.87 (5.34–6.82) | 7.19 (6.43–9.83) | < 0.001 |
Urea (mmol/L) | 3.59 (3.02–4.56) | 5.71 (4.42–6.58) | < 0.001 |
Creatinine (µmol/L) | 69.00 (59.00–82.00) | 70.00 (59.50–76.25) | 0.941 |
Uric acid (µmol/L) | 259.00 (206.00–301.00) | 204.50 (139.75–296.50) | 0.068 |
Carbon dioxide (mmol/L) | 25.30 (23.80–27.40) | 25.70 (23.37–27.93) | 0.728 |
Potassium (mmol/L) | 3.99 (3.71–4.33) | 3.97 (3.76–4.09) | 0.538 |
Sodium (mmol/L) | 138.00 (137.00–139.00) | 137.00 (134.00–138.00) | 0.002 |
Chlorine (mmol/L) | 102.40 (100.90–104.00) | 101.05 (97.95–102.82) | 0.009 |
Calcium (mmol/L) | 2.27 (2.18–2.32) | 2.12 (2.08–2.19) | < 0.001 |
Phosphorus (mmol/L) | 1.10 (0.97–1.20) | 0.96 (0.89–1.14) | 0.029 |
Magnesium (mmol/L) | 0.87 (0.82–0.95) | 0.92 (0.83–1.00) | 0.06 |
Creatine kinase (U/L) | 91.70 (55.10–150.10) | 87.00 (61.05–167.65) | 0.996 |
CKMB (U/L) | 11.20 (9.10–15.80) | 10.00 (9.00–13.00) | 0.273 |
LDH (U/L) | 205.00 (173.00–269.00) | 284.00 (251.50–331.50) | < 0.001 |
Myohemoglobin (ng/mL) | 30.00 (27.00–33.00) | 36.00 (30.00–68.00) | 0.004 |
Infection-related biomarkers | |||
Procalcitonin (ng/mL) | 0.14 (0.10–0.16) | 0.18 (0.13–0.23) | 0.002 |
Interleukin-6 (pg/ml) | 6.20 (5.25–6.83) | 7.26 (6.66–9.91) | < 0.001 |
SAA (mg/L) | 75.00 (18.43–175.40) | 167.50 (118.50–209.88) | < 0.001 |
CRP (mg/L) | 5.25 (2.00–21.93) | 43.40 (14.52–96.05) | < 0.001 |